@article{Seydou2022-es,

title = {Plasma fatty acids pattern and dry eye disease in the elderly: 

 The Montrachet population-based study},

author = {Alassane Seydou and Louis Arnould and Pierre-Henry Gabrielle and Florian Baudin and Ines Ben Ghezala and Alain M Bron and Niyazi Acar and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-05-01},

journal = {Nutrients},

volume = {14},

number = {11},

pages = {2290},

publisher = {MDPI AG},

abstract = {(1) Background: To investigate the association between plasma 

 fatty acids (FAs) and dry eye disease (DED) in an elderly 

 population; (2) Methods: We conducted a population-based study, 

 the Montrachet study, in individuals older than 75 years. DED 

 was evaluated using the Schirmer I test without anesthesia, tear 

 film breakup time (TFBUT) measurement and fluorescein corneal 

 staining. Plasma FAs were measured in fasting blood using gas 

 chromatography; (3) Results: A total of 740 subjects with a 

 plasma measurement of 25 FAs were included in this study. The 

 mean age was 82.2 $±$ 3.7 years, and 62.7% were women. DED 

 was present in 35.0% of participants. We identified a plasma 

 FAs pattern positively associated with DED, characterized by low 

 polyunsaturated fatty acids (PUFAs), high monounsaturated fatty 

 acids (MUFAs) and low saturated fatty acids (SFAs) levels. After 

 adjustment for major confounders, individuals in the upper 

 quartile of the FAs pattern scores compared with those in the 

 lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51-4.01},

keywords = {dry eye disease; elderly; epidemiology; fatty acids pattern;   lipids; ocular surface; population-based study},

pubstate = {published},

tppubtype = {article}

}