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Publications du département d'ophtalmologie

Bienvenue sur la page dédiée aux publications scientifiques du département d'ophtalmologie du centre médical des Aravis. Notre équipe médicale s'investit activement dans la recherche et l'innovation afin d'améliorer constamment la prise en charge de nos patients. Nos travaux portent sur un large éventail de thématiques, notamment :

Domaines d'expertise

Les maladies de la cornée, telles que le kératocône, et les techniques chirurgicales associées (greffe de cornée, etc.).
Les pathologies rétiniennes, comme la DMLA ou le décollement de la rétine, avec une expertise particulière dans les traitements par injections intravitréennes et la chirurgie vitréo-rétinienne.
L'épidémiologie et la santé publique en ophtalmologie, en utilisant des bases de données nationales pour analyser les tendances et les facteurs de risque de différentes maladies oculaires.
L'impact des technologies numériques sur la santé oculaire, notamment l'utilisation de la télémédecine pour le dépistage de la rétinopathie diabétique.

Nous sommes fiers de partager ici nos contributions à l'avancement des connaissances en ophtalmologie. N'hésitez pas à consulter nos publications pour en savoir plus sur nos domaines d'expertise et nos recherches en cours.

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2021

Chemaly, Alicia; Arnould, Louis; Seydou, Alassane; Gabrielle, Pierre-Henry; Baudin, Florian; Acar, Niyazi; Creuzot-Garcher, Catherine

Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study Article de journal

Dans: BMC Ophthalmol., vol. 21, no. 1, p. 146, 2021.

Résumé | BibTeX | Étiquettes: Elderly; Fatty acids profile; Glaucoma; Montrachet study; Population-based study

@article{Chemaly2021-bt,

title = {Plasma fatty acids and primary open-angle glaucoma in the 

 elderly: the Montrachet population-based study},

author = {Alicia Chemaly and Louis Arnould and Alassane Seydou and Pierre-Henry Gabrielle and Florian Baudin and Niyazi Acar and Catherine Creuzot-Garcher},

year  = {2021},

date = {2021-03-01},

journal = {BMC Ophthalmol.},

volume = {21},

number = {1},

pages = {146},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: To compare plasma fatty acids (FAs) between 

 participants with primary open-angle glaucoma (POAG) and 

 participants without neuropathy in an elderly population and to 

 investigate specific FAs pattern in POAG. METHODS: We conducted 

 a population-based study in participants older than 75 years. 

 Participants underwent a comprehensive eye examination with 

 optic nerve photographs, visual field test and optic nerve OCT 

 with RNFL thickness measurement. Glaucomatous status was defined 

 according to the International Society for Epidemiologic and 

 Geographical Ophthalmology classification. Lipids were extracted 

 from plasma and FAs methylesters prepared and analyzed by gas 

 chromatography-mass spectrometry. RESULTS: Among the 1153 

 participants of the Montrachet study 810 were retained for 

 analysis and 68 had POAG. The mean age was 82.11 $±$ 3.67. In 

 multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern 

 characterized by high negative weight of gamma-linoleic acid, 

 eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 

 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive 

 weight of eicosadienoic acid, docosatetraenoic acid, 

 docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid 

 MUFAs, margaric acid and behenic acid saturated FAs was 

 positively associated with POAG. After adjustment for major 

 confounders, individuals in the upper tertile of FAs pattern 

 scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29-7.40] P = 0.013). 

 CONCLUSIONS: We found no significant difference regarding 

 isolated plasma FAs between participants with POAG and 

 participants without neuropathy in elderly but specific FAs 

 pattern might be associated with POAG.},

keywords = {Elderly; Fatty acids profile; Glaucoma; Montrachet study;   Population-based study},

pubstate = {published},

tppubtype = {article}

}

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Chemaly, Alicia; Arnould, Louis; Seydou, Alassane; Gabrielle, Pierre-Henry; Baudin, Florian; Acar, Niyazi; Creuzot-Garcher, Catherine

Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study Article de journal

Dans: BMC Ophthalmol., vol. 21, no. 1, p. 146, 2021.

Résumé | BibTeX

@article{Chemaly2021-bt,

title = {Plasma fatty acids and primary open-angle glaucoma in the 

 elderly: the Montrachet population-based study},

author = {Alicia Chemaly and Louis Arnould and Alassane Seydou and Pierre-Henry Gabrielle and Florian Baudin and Niyazi Acar and Catherine Creuzot-Garcher},

year  = {2021},

date = {2021-03-01},

journal = {BMC Ophthalmol.},

volume = {21},

number = {1},

pages = {146},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: To compare plasma fatty acids (FAs) between 

 participants with primary open-angle glaucoma (POAG) and 

 participants without neuropathy in an elderly population and to 

 investigate specific FAs pattern in POAG. METHODS: We conducted 

 a population-based study in participants older than 75 years. 

 Participants underwent a comprehensive eye examination with 

 optic nerve photographs, visual field test and optic nerve OCT 

 with RNFL thickness measurement. Glaucomatous status was defined 

 according to the International Society for Epidemiologic and 

 Geographical Ophthalmology classification. Lipids were extracted 

 from plasma and FAs methylesters prepared and analyzed by gas 

 chromatography-mass spectrometry. RESULTS: Among the 1153 

 participants of the Montrachet study 810 were retained for 

 analysis and 68 had POAG. The mean age was 82.11 $±$ 3.67. In 

 multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern 

 characterized by high negative weight of gamma-linoleic acid, 

 eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 

 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive 

 weight of eicosadienoic acid, docosatetraenoic acid, 

 docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid 

 MUFAs, margaric acid and behenic acid saturated FAs was 

 positively associated with POAG. After adjustment for major 

 confounders, individuals in the upper tertile of FAs pattern 

 scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29-7.40] P = 0.013). 

 CONCLUSIONS: We found no significant difference regarding 

 isolated plasma FAs between participants with POAG and 

 participants without neuropathy in elderly but specific FAs 

 pattern might be associated with POAG.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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