@article{Arnould2022-jn,

title = {Repeatability and reproducibility of retinal fractal dimension 

 measured with swept-source optical coherence tomography 

 angiography in healthy eyes: A proof-of-concept study},

author = {Louis Arnould and Déa Haddad and Florian Baudin and Pierre-Henry Gabrielle and Marc Sarossy and Alain M Bron and Behzad Aliahmad and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-07-01},

journal = {Diagnostics (Basel)},

volume = {12},

number = {7},

pages = {1769},

publisher = {MDPI AG},

abstract = {The retinal vascular network fractal dimension (FD) could be a 

 promising imaging biomarker. Our objective was to evaluate its 

 repeatability and reproducibility in healthy eyes. A 

 cross-sectional study was undertaken with young, healthy 

 volunteers who had no reported cardiac risk factors or ocular 

 disease history. For each participant, three SS-OCTA images (12 

 $times$ 12 mm) were acquired using the Plex Elite 9000 (Carl 

 Zeiss Meditec AG, Jena, Germany) by two ophthalmologists. 

 Automated segmentation was obtained from both the superficial 

 and deep capillary plexuses. FD was estimated by box counting. 

 The intraclass correlation coefficients (ICC) were used as 

 measures for repeatability and reproducibility. A total of 43 

 eyes of healthy volunteers were included. The mean $±$ 

 standard deviation (SD) age was 30 $±$ 6.2 years. The results 

 show good repeatability. The ICC was 0.722 (95% CI, 

 0.541-0.839) in the superficial capillary plexus and 0.828 (95% 

 CI, 0.705-0.903) in the deep capillary plexus. For 

 reproducibility, the ICC was 0.651 (95% CI, 0.439-0.795) and 

 0.363 (95% CI, 0.073-0.596) at the superficial and deep 

 capillary plexus, respectively. In this study, the FD of the 

 vascular network measured via SS-OCTA showed good repeatability 

 and reproducibility in healthy participants.},

keywords = {deep retinal capillary plexus; fractal dimension; healthy   volunteers; retina; superficial retinal capillary plexus;   swept-source OCT angiography; vascular imaging},

pubstate = {published},

tppubtype = {article}

}