Liste des publications
Publications du département d'ophtalmologie
Bienvenue sur la page dédiée aux publications scientifiques du département d'ophtalmologie du centre médical des Aravis. Notre équipe médicale s'investit activement dans la recherche et l'innovation afin d'améliorer constamment la prise en charge de nos patients. Nos travaux portent sur un large éventail de thématiques, notamment :
Domaines d'expertise
- Les maladies de la cornée, telles que le kératocône, et les techniques chirurgicales associées (greffe de cornée, etc.).
- Les pathologies rétiniennes, comme la DMLA ou le décollement de la rétine, avec une expertise particulière dans les traitements par injections intravitréennes et la chirurgie vitréo-rétinienne.
- L'épidémiologie et la santé publique en ophtalmologie, en utilisant des bases de données nationales pour analyser les tendances et les facteurs de risque de différentes maladies oculaires.
- L'impact des technologies numériques sur la santé oculaire, notamment l'utilisation de la télémédecine pour le dépistage de la rétinopathie diabétique.
Nous sommes fiers de partager ici nos contributions à l'avancement des connaissances en ophtalmologie. N'hésitez pas à consulter nos publications pour en savoir plus sur nos domaines d'expertise et nos recherches en cours.
2023
Carré, Chloé; Baudin, Florian; Buteau, Bénédicte; Martine, Lucy; Grégoire, Stéphane; Vasku, Glenda; Berdeaux, Olivier; Béduneau, Arnaud; Pellequer, Yann; Jamoussi, Jasmine; Desrumeaux, Catherine; Aho, Serge; Bron, Alain-Marie; Acar, Niyazi; Creuzot-Garcher, Catherine; Gabrielle, Pierre Henri
Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery Article de journal
Dans: Acta Ophthalmol., vol. 101, no. 1, p. e61–e68, 2023.
Résumé | BibTeX | Étiquettes: docosahexaenoic acid; fibrosis; glaucoma; glaucoma surgery
@article{Carre2023-te,
title = {Effects of topical docosahexaenoic acid on postoperative
fibrosis in an animal model of glaucoma filtration surgery},
author = {Chloé Carré and Florian Baudin and Bénédicte Buteau and Lucy Martine and Stéphane Grégoire and Glenda Vasku and Olivier Berdeaux and Arnaud Béduneau and Yann Pellequer and Jasmine Jamoussi and Catherine Desrumeaux and Serge Aho and Alain-Marie Bron and Niyazi Acar and Catherine Creuzot-Garcher and Pierre Henri Gabrielle},
year = {2023},
date = {2023-02-01},
journal = {Acta Ophthalmol.},
volume = {101},
number = {1},
pages = {e61–e68},
publisher = {Wiley},
abstract = {PURPOSE: The aim of this study was to evaluate docosahexaenoic
acid (DHA) as a potential antifibrotic agent after glaucoma
filtration surgery (GFS) in rats. METHODS: A total of 36
10-week-old Brown Norway rats underwent GFS. Animals were
equally divided into three groups: a control group, a DHA group
and a mitomycin C (MMC) group. Intraocular pressure (IOP) was
measured using a dynamic rebound tonometer, and a photograph of
the surgical site was taken on days 1, 3, 7, 10, 14 and 17. The
incorporation of DHA into fibroblasts was evaluated by gas
chromatography. The expression of alfa-smooth muscle actin
(α-SMA) and Smad proteins was assessed by Western
blotting. RESULTS: IOP decreased after surgery in animals from
the three groups on day 1 after surgery. Over time, IOP remained
lower in the DHA and MMC groups than in the control group
(median [interquartile range] 8.0 [7.0-8.0] and 8.0 [7.3-8.0]
mmHg vs. 9.0 [8.0-9.0] mmHg, respectively; p < 0.001). Bleb area
in the DHA and MMC groups remained larger than that of the
control group from day 7 to day 14 (3.9 [2.9-5.2] and 3.5 [2.3-4.4] mm2 vs. 2.3 [2.0-2.8] mm2 , respectively; p = 0.0021).
We did not observe any change in DHA concentrations in the
fibroblasts of the DHA group compared with the other groups.
CONCLUSION: The impact of DHA on IOP and bleb area was similar
to that of MMC. The mechanisms of action of DHA in rat eye
fibroblasts deserve further investigation.},
keywords = {docosahexaenoic acid; fibrosis; glaucoma; glaucoma surgery},
pubstate = {published},
tppubtype = {article}
}
acid (DHA) as a potential antifibrotic agent after glaucoma
filtration surgery (GFS) in rats. METHODS: A total of 36
10-week-old Brown Norway rats underwent GFS. Animals were
equally divided into three groups: a control group, a DHA group
and a mitomycin C (MMC) group. Intraocular pressure (IOP) was
measured using a dynamic rebound tonometer, and a photograph of
the surgical site was taken on days 1, 3, 7, 10, 14 and 17. The
incorporation of DHA into fibroblasts was evaluated by gas
chromatography. The expression of alfa-smooth muscle actin
(α-SMA) and Smad proteins was assessed by Western
blotting. RESULTS: IOP decreased after surgery in animals from
the three groups on day 1 after surgery. Over time, IOP remained
lower in the DHA and MMC groups than in the control group
(median [interquartile range] 8.0 [7.0-8.0] and 8.0 [7.3-8.0]
mmHg vs. 9.0 [8.0-9.0] mmHg, respectively; p < 0.001). Bleb area
in the DHA and MMC groups remained larger than that of the
control group from day 7 to day 14 (3.9 [2.9-5.2] and 3.5 [2.3-4.4] mm2 vs. 2.3 [2.0-2.8] mm2 , respectively; p = 0.0021).
We did not observe any change in DHA concentrations in the
fibroblasts of the DHA group compared with the other groups.
CONCLUSION: The impact of DHA on IOP and bleb area was similar
to that of MMC. The mechanisms of action of DHA in rat eye
fibroblasts deserve further investigation.
Explorer
Recherche
Carré, Chloé; Baudin, Florian; Buteau, Bénédicte; Martine, Lucy; Grégoire, Stéphane; Vasku, Glenda; Berdeaux, Olivier; Béduneau, Arnaud; Pellequer, Yann; Jamoussi, Jasmine; Desrumeaux, Catherine; Aho, Serge; Bron, Alain-Marie; Acar, Niyazi; Creuzot-Garcher, Catherine; Gabrielle, Pierre Henri
Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery Article de journal
Dans: Acta Ophthalmol., vol. 101, no. 1, p. e61–e68, 2023.
@article{Carre2023-te,
title = {Effects of topical docosahexaenoic acid on postoperative
fibrosis in an animal model of glaucoma filtration surgery},
author = {Chloé Carré and Florian Baudin and Bénédicte Buteau and Lucy Martine and Stéphane Grégoire and Glenda Vasku and Olivier Berdeaux and Arnaud Béduneau and Yann Pellequer and Jasmine Jamoussi and Catherine Desrumeaux and Serge Aho and Alain-Marie Bron and Niyazi Acar and Catherine Creuzot-Garcher and Pierre Henri Gabrielle},
year = {2023},
date = {2023-02-01},
journal = {Acta Ophthalmol.},
volume = {101},
number = {1},
pages = {e61–e68},
publisher = {Wiley},
abstract = {PURPOSE: The aim of this study was to evaluate docosahexaenoic
acid (DHA) as a potential antifibrotic agent after glaucoma
filtration surgery (GFS) in rats. METHODS: A total of 36
10-week-old Brown Norway rats underwent GFS. Animals were
equally divided into three groups: a control group, a DHA group
and a mitomycin C (MMC) group. Intraocular pressure (IOP) was
measured using a dynamic rebound tonometer, and a photograph of
the surgical site was taken on days 1, 3, 7, 10, 14 and 17. The
incorporation of DHA into fibroblasts was evaluated by gas
chromatography. The expression of alfa-smooth muscle actin
(α-SMA) and Smad proteins was assessed by Western
blotting. RESULTS: IOP decreased after surgery in animals from
the three groups on day 1 after surgery. Over time, IOP remained
lower in the DHA and MMC groups than in the control group
(median [interquartile range] 8.0 [7.0-8.0] and 8.0 [7.3-8.0]
mmHg vs. 9.0 [8.0-9.0] mmHg, respectively; p < 0.001). Bleb area
in the DHA and MMC groups remained larger than that of the
control group from day 7 to day 14 (3.9 [2.9-5.2] and 3.5 [2.3-4.4] mm2 vs. 2.3 [2.0-2.8] mm2 , respectively; p = 0.0021).
We did not observe any change in DHA concentrations in the
fibroblasts of the DHA group compared with the other groups.
CONCLUSION: The impact of DHA on IOP and bleb area was similar
to that of MMC. The mechanisms of action of DHA in rat eye
fibroblasts deserve further investigation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
acid (DHA) as a potential antifibrotic agent after glaucoma
filtration surgery (GFS) in rats. METHODS: A total of 36
10-week-old Brown Norway rats underwent GFS. Animals were
equally divided into three groups: a control group, a DHA group
and a mitomycin C (MMC) group. Intraocular pressure (IOP) was
measured using a dynamic rebound tonometer, and a photograph of
the surgical site was taken on days 1, 3, 7, 10, 14 and 17. The
incorporation of DHA into fibroblasts was evaluated by gas
chromatography. The expression of alfa-smooth muscle actin
(α-SMA) and Smad proteins was assessed by Western
blotting. RESULTS: IOP decreased after surgery in animals from
the three groups on day 1 after surgery. Over time, IOP remained
lower in the DHA and MMC groups than in the control group
(median [interquartile range] 8.0 [7.0-8.0] and 8.0 [7.3-8.0]
mmHg vs. 9.0 [8.0-9.0] mmHg, respectively; p < 0.001). Bleb area
in the DHA and MMC groups remained larger than that of the
control group from day 7 to day 14 (3.9 [2.9-5.2] and 3.5 [2.3-4.4] mm2 vs. 2.3 [2.0-2.8] mm2 , respectively; p = 0.0021).
We did not observe any change in DHA concentrations in the
fibroblasts of the DHA group compared with the other groups.
CONCLUSION: The impact of DHA on IOP and bleb area was similar
to that of MMC. The mechanisms of action of DHA in rat eye
fibroblasts deserve further investigation.