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Publications du département d'ophtalmologie

Bienvenue sur la page dédiée aux publications scientifiques du département d'ophtalmologie du centre médical des Aravis. Notre équipe médicale s'investit activement dans la recherche et l'innovation afin d'améliorer constamment la prise en charge de nos patients. Nos travaux portent sur un large éventail de thématiques, notamment :

Domaines d'expertise

Les maladies de la cornée, telles que le kératocône, et les techniques chirurgicales associées (greffe de cornée, etc.).
Les pathologies rétiniennes, comme la DMLA ou le décollement de la rétine, avec une expertise particulière dans les traitements par injections intravitréennes et la chirurgie vitréo-rétinienne.
L'épidémiologie et la santé publique en ophtalmologie, en utilisant des bases de données nationales pour analyser les tendances et les facteurs de risque de différentes maladies oculaires.
L'impact des technologies numériques sur la santé oculaire, notamment l'utilisation de la télémédecine pour le dépistage de la rétinopathie diabétique.

Nous sommes fiers de partager ici nos contributions à l'avancement des connaissances en ophtalmologie. N'hésitez pas à consulter nos publications pour en savoir plus sur nos domaines d'expertise et nos recherches en cours.

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2022

Baudin, Florian; Benzenine, Eric; Mariet, Anne-Sophie; Ghezala, Inès Ben; Bron, Alain M; Daien, Vincent; Gabrielle, Pierre-Henry; Quantin, Catherine; Creuzot-Garcher, Catherine

Topical antibiotic prophylaxis and intravitreal injections: Impact on the incidence of acute endophthalmitis-A nationwide study in France from 2009 to 2018 Article de journal

Dans: Pharmaceutics, vol. 14, no. 10, p. 2133, 2022.

Résumé | BibTeX | Étiquettes: IVT; antibiotics; endophthalmitis; intravitreal injection

@article{Baudin2022-mg,

title = {Topical antibiotic prophylaxis and intravitreal injections: 

 Impact on the incidence of acute endophthalmitis-A nationwide 

 study in France from 2009 to 2018},

author = {Florian Baudin and Eric Benzenine and Anne-Sophie Mariet and Inès Ben Ghezala and Alain M Bron and Vincent Daien and Pierre-Henry Gabrielle and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-10-01},

journal = {Pharmaceutics},

volume = {14},

number = {10},

pages = {2133},

publisher = {MDPI AG},

abstract = {Background: The dramatic increase in intravitreal injections 

 (IVTs) has been accompanied by a greater need for safer 

 procedures. The ongoing debate about topical antibiotic 

 prophylaxis after IVTs emphasizes the importance of large-scale 

 studies. We aimed to study the role of topical antibiotic 

 prophylaxis in reducing the risk of acute endophthalmitis after 

 IVTs. Methods: Population-based cohort study, in France, from 

 2009 to 2018, including all French patients receiving IVTs of 

 corticosteroids or anti-VEGF agents. Results: A total of 

 5,291,420 IVTs were performed on 605,434 patients. The rate of 

 topical antibiotic prophylaxis after IVTs progressively 

 decreased during the study period, with a sharp drop in 2014 

 (from 84.6% in 2009 to 27.4% in 2018). Acute endophthalmitis occurred in 1274 cases (incidence rate = 0.0241%). Although 

 antibiotic prophylaxis did not alter the risk of endophthalmitis (p = 0.06), univariate analysis showed an increased risk after 

 fluoroquinolone and aminoglycoside prophylaxis. This increased 

 risk was not found in multivariate analysis. However, we 

 observed an increased risk related to the use of fixed 

 combinations of fluoroquinolones and aminoglycosides with corticosteroids (IRR = 1.89; 95% CI = 1.57-2.27%, antibiotics 

 combined with corticosteroids). Conclusion: These results are 

 consistent with the literature. Endophthalmitis rates after IVTs 

 did not decrease with topical antibiotic prophylaxis. The use of 

 a combination of antibiotics and corticosteroids doubles the 

 risk of endophthalmitis and should be avoided. Avoiding 

 antibiotic prophylaxis would reduce the costs and the potential 

 risks of antibiotic resistance.},

keywords = {IVT; antibiotics; endophthalmitis; intravitreal injection},

pubstate = {published},

tppubtype = {article}

}

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Baudin, Florian; Benzenine, Eric; Mariet, Anne-Sophie; Ghezala, Inès Ben; Bron, Alain M; Daien, Vincent; Gabrielle, Pierre-Henry; Quantin, Catherine; Creuzot-Garcher, Catherine

Topical antibiotic prophylaxis and intravitreal injections: Impact on the incidence of acute endophthalmitis-A nationwide study in France from 2009 to 2018 Article de journal

Dans: Pharmaceutics, vol. 14, no. 10, p. 2133, 2022.

Résumé | BibTeX

@article{Baudin2022-mg,

title = {Topical antibiotic prophylaxis and intravitreal injections: 

 Impact on the incidence of acute endophthalmitis-A nationwide 

 study in France from 2009 to 2018},

author = {Florian Baudin and Eric Benzenine and Anne-Sophie Mariet and Inès Ben Ghezala and Alain M Bron and Vincent Daien and Pierre-Henry Gabrielle and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-10-01},

journal = {Pharmaceutics},

volume = {14},

number = {10},

pages = {2133},

publisher = {MDPI AG},

abstract = {Background: The dramatic increase in intravitreal injections 

 (IVTs) has been accompanied by a greater need for safer 

 procedures. The ongoing debate about topical antibiotic 

 prophylaxis after IVTs emphasizes the importance of large-scale 

 studies. We aimed to study the role of topical antibiotic 

 prophylaxis in reducing the risk of acute endophthalmitis after 

 IVTs. Methods: Population-based cohort study, in France, from 

 2009 to 2018, including all French patients receiving IVTs of 

 corticosteroids or anti-VEGF agents. Results: A total of 

 5,291,420 IVTs were performed on 605,434 patients. The rate of 

 topical antibiotic prophylaxis after IVTs progressively 

 decreased during the study period, with a sharp drop in 2014 

 (from 84.6% in 2009 to 27.4% in 2018). Acute endophthalmitis occurred in 1274 cases (incidence rate = 0.0241%). Although 

 antibiotic prophylaxis did not alter the risk of endophthalmitis (p = 0.06), univariate analysis showed an increased risk after 

 fluoroquinolone and aminoglycoside prophylaxis. This increased 

 risk was not found in multivariate analysis. However, we 

 observed an increased risk related to the use of fixed 

 combinations of fluoroquinolones and aminoglycosides with corticosteroids (IRR = 1.89; 95% CI = 1.57-2.27%, antibiotics 

 combined with corticosteroids). Conclusion: These results are 

 consistent with the literature. Endophthalmitis rates after IVTs 

 did not decrease with topical antibiotic prophylaxis. The use of 

 a combination of antibiotics and corticosteroids doubles the 

 risk of endophthalmitis and should be avoided. Avoiding 

 antibiotic prophylaxis would reduce the costs and the potential 

 risks of antibiotic resistance.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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