@article{Mehta2024-mq,

title = {One-year anti-VEGF therapy outcomes in diabetic macular edema 

 based on treatment intensity: Data from the Fight Retinal 

 Blindness! Registry},

author = {Hemal Mehta and Pierre-Henry Gabrielle and Yohei Hashimoto and Getiye Dejenu Kibret and Jennifer Arnold and Tremeur Guillaumie and Wajiha Jurdi Kheir and Gerhard Kok and Stela Vujosevic and Louise O'Toole and Els Mangelschots and Nandor Jaross and Lala Ceklic and Vincent Daien and Francesco Viola and David Squirrell and Francisco Javier Lavid and Catherine Creuzot-Garcher and Daniel Barthelmes and Mark Gillies and Fight Retinal Blindness! Study Group},

year  = {2024},

date = {2024-09-01},

journal = {Ophthalmol. Retina},

volume = {8},

number = {9},

pages = {872–879},

publisher = {Elsevier BV},

abstract = {PURPOSE: To compare one-year outcomes of eyes with diabetic 

 macular edema (DME) treated in routine clinical practice based 

 on the proportion of visits where intravitreal vascular 

 endothelial growth factor (VEGF) inhibitor injections were 

 delivered. DESIGN: Cohort study PARTICIPANTS: There were 2288 

 treatment-naïve eyes with DME starting intravitreal VEGF 

 inhibitor therapy from 31 October 2015 to 31 October 2021 from 

 the Fight Retinal Blindness! international outcomes registry. 

 METHODS: Eyes were grouped according to the proportion of visits 

 at which an injection was received, Group A with less than the median of 67% (n=1172) versus Group B with greater than the median (n=1116). MAIN OUTCOME MEASURE: Mean visual acuity (VA) 

 change after 12 months of treatment. RESULTS: The mean (95% 

 confidence interval [CI]) VA change after 12 months of treatment 

 was 3.6 (2.8, 4.4) letters for eyes in Group A versus 5.2 (4.4, 5.9) letters for eyes in Group B (p=0.005). The mean (95% CI) 

 central subfield thickness (CST) change was -69 (-76, -61) 

 μm and -85 (-92, -78) μm for eyes in Group A versus Group B, respectively (p=0.002). A moderate positive correlation 

 was observed between the number of injections received over 12 

 months of treatment and the change in VA (p<0.001). 

 Additionally, eyes that received more injections had a 

 moderately greater CST reduction. CONCLUSIONS: This registry 

 analysis found that overall VA and anatomic outcomes tended to 

 be better in DME eyes treated at a greater proportion of visits 

 in the first year of intravitreal VEGF inhibitor therapy.},

keywords = {Anti-VEGF; Diabetic macular edema; Pro re nata; Real-world   evidence; Treat-and-extend},

pubstate = {published},

tppubtype = {article}

}

@article{Mathis2024-mh,

title = {DRD2 activation inhibits choroidal neovascularization in  patients with Parkinson's disease and age-related macular  degeneration},

author = {Thibaud Mathis and Florian Baudin and Anne-Sophie Mariet and Sébastien Augustin and Marion Bricout and Lauriane Przegralek and Christophe Roubeix and Éric Benzenine and Guillaume Blot and Caroline Nous and Laurent Kodjikian and Martine Mauget-Faÿsse and José-Alain Sahel and Robin Plevin and Christina Zeitz and Cécile Delarasse and Xavier Guillonneau and Catherine Creuzot-Garcher and Catherine Quantin and Stéphane Hunot and Florian Sennlaub},

url = {https://annecy-ophtalmo.fr/wp-content/uploads/2024/10/jci-134-174199.pdf},

year  = {2024},

date = {2024-07-01},

urldate = {2024-07-01},

journal = {J. Clin. Invest.},

volume = {134},

number = {17},

publisher = {American Society for Clinical Investigation},

abstract = {Neovascular age-related macular degeneration (nAMD) remains a 

 major cause of visual impairment and puts considerable burden on 

 patients and health care systems. l-DOPA-treated Parkinson's 

 disease (PD) patients have been shown to be partially protected 

 from nAMD, but the mechanism remains unknown. Using murine 

 models that combine 

 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced 

 (MPTP-induced) PD and laser-induced nAMD with standard PD 

 treatment of l-DOPA/DOPA-decarboxylase inhibitor or specific 

 dopamine receptor inhibitors, we here demonstrate that l-DOPA 

 treatment-induced increase of dopamine-mediated dopamine 

 receptor D2 (DRD2) signaling inhibits choroidal 

 neovascularization independently of MPTP-associated 

 nigrostriatal pathway lesion. Analyzing a retrospective cohort 

 of more than 200,000 patients with nAMD receiving anti-VEGF 

 treatment from the French nationwide insurance database, we show 

 that DRD2 agonist-treated PD patients have a significantly 

 delayed age of onset of nAMD and reduced need for anti-VEGF 

 therapies, similar to the effects of the l-DOPA treatment. While 

 providing a mechanistic explanation for an intriguing 

 epidemiological observation, our findings suggest that systemic 

 DRD2 agonists might constitute an adjuvant therapy to delay and 

 reduce the need for anti-VEGF therapy in patients with nAMD.},

keywords = {Neurodegeneration; Neuroscience; Ophthalmology; Parkinson   disease; Retinopathy},

pubstate = {published},

tppubtype = {article}

}

@article{Mathis2024-ch,

title = {DRD2 activation inhibits choroidal neovascularization in 

 patients with Parkinson's disease and age-related macular 

 degeneration},

author = {Thibaud Mathis and Florian Baudin and Anne-Sophie Mariet and Sébastien Augustin and Marion Bricout and Lauriane Przegralek and Christophe Roubeix and Éric Benzenine and Guillaume Blot and Caroline Nous and Laurent Kodjikian and Martine Mauget-Faÿsse and José-Alain Sahel and Robin Plevin and Christina Zeitz and Cécile Delarasse and Xavier Guillonneau and Catherine Creuzot-Garcher and Catherine Quantin and Stéphane Hunot and Florian Sennlaub},

year  = {2024},

date = {2024-07-01},

journal = {J. Clin. Invest.},

volume = {134},

number = {17},

publisher = {American Society for Clinical Investigation},

abstract = {Neovascular age-related macular degeneration (nAMD) remains a 

 major cause of visual impairment and puts considerable burden on 

 patients and health care systems. l-DOPA-treated Parkinson's 

 disease (PD) patients have been shown to be partially protected 

 from nAMD, but the mechanism remains unknown. Using murine 

 models that combine 

 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced 

 (MPTP-induced) PD and laser-induced nAMD with standard PD 

 treatment of l-DOPA/DOPA-decarboxylase inhibitor or specific 

 dopamine receptor inhibitors, we here demonstrate that l-DOPA 

 treatment-induced increase of dopamine-mediated dopamine 

 receptor D2 (DRD2) signaling inhibits choroidal 

 neovascularization independently of MPTP-associated 

 nigrostriatal pathway lesion. Analyzing a retrospective cohort 

 of more than 200,000 patients with nAMD receiving anti-VEGF 

 treatment from the French nationwide insurance database, we show 

 that DRD2 agonist-treated PD patients have a significantly 

 delayed age of onset of nAMD and reduced need for anti-VEGF 

 therapies, similar to the effects of the l-DOPA treatment. While 

 providing a mechanistic explanation for an intriguing 

 epidemiological observation, our findings suggest that systemic 

 DRD2 agonists might constitute an adjuvant therapy to delay and 

 reduce the need for anti-VEGF therapy in patients with nAMD.},

keywords = {Neurodegeneration; Neuroscience; Ophthalmology; Parkinson   disease; Retinopathy},

pubstate = {published},

tppubtype = {article}

}

@article{Vaitinadapoule2024-fz,

title = {Nanotopography by chromatic confocal microscopy of the 

 endothelium in Fuchs endothelial corneal dystrophy, pseudophakic 

 bullous keratopathy and healthy corneas},

author = {Hanielle Vaitinadapoulé and Sylvain Poinard and Zhiguo He and Alina Pascale-Hamri and Justin Thomas and Philippe Gain and Jean-Yves Thuret and Frédéric Mascarelli and Gilles Thuret and French Fuchs Study Group (FFSG)},

year  = {2024},

date = {2024-07-01},

journal = {Br. J. Ophthalmol.},

volume = {108},

number = {8},

pages = {1184–1192},

publisher = {BMJ},

abstract = {AIM: To investigate the interest of chromatic confocal 

 microscopy (CCM) to characterise guttae in Fuchs endothelial 

 corneal dystrophy (FECD). METHODS: Descemet's membranes (DM) 

 were obtained during endothelial keratoplasty in patients with 

 FECD and pseudophakic bullous keratopathy (PBK). They were 

 compared with healthy samples obtained from body donation to 

 science. Samples were fixed in 0.5% paraformaldehyde and flat 

 mounted. Surface roughness of DMs was quantified using CCM and 

 the AltiMap software that provided the maximum peak (Sp) and 

 valley (Sv) heights, the mean square roughness (Rq) and the 

 asymmetry coefficient (Ssk). RESULTS: The physiological 

 roughness of healthy samples was characterised by an Rq of 

 0.12$±$0.05 µm, which was two times rougher than in PBK (Rq=0.06$±$0.03 µm), but both were still flat with a 

 symmetrical distribution between peaks and valleys (Ssk close to},

keywords = {Cornea; Dystrophy; Imaging; Pathology; Physiology},

pubstate = {published},

tppubtype = {article}

}

@article{Creuzot_Garcher2024-wm,

title = {Management of diabetic macular oedema in France from 2012 to 

 2018: The nationwide LANDSCAPE study},

author = {Catherine P Creuzot Garcher and Pascale Massin and Mayer Srour and Florian Baudin and Corinne Dot and Sylvia Nghiem-Buffet and Jean-Francois Girmens and Cedric Collin and Anne Ponthieux and Cecile Delcourt},

year  = {2024},

date = {2024-06-01},

journal = {Acta Ophthalmol.},

volume = {102},

number = {4},

pages = {e548–e556},

publisher = {Wiley},

abstract = {OBJECTIVE: To describe the management of diabetic macular oedema 

 (DME) patients from the entire French population between 2012 

 and 2018. METHODS: In this retrospective longitudinal study, we 

 identified adults treated for DME from the French population 

 using the exhaustive French National Health Information database 

 (SNDS), and an algorithm based on diagnosis and procedure codes, 

 and reimbursed treatments. RESULTS: Between 2012 and 2018, we 

 identified 53 584 treated DME patients, who were followed for up 

 to 7 years from DME treatment initiation. Optical coherence 

 tomography (OCT) became the predominant imaging tool to diagnose 

 DME. Only 14% of patients consulted a diabetologist or 

 endocrinologist in the 3 months prior to initiating DME 

 treatment, whereas 84% consulted a general practitioner. The 

 percentage of patients consulting an ophthalmologist declined 

 over time, from 97% of patients in Year 1 (median of 9 

 consultations), to 46% in Year 7 (median of 7 consultations). 

 The median DME treatment duration with an anti-VEGF and/or 

 dexamethasone implant treatment was 9 months; 54% of patients 

 had a treatment duration less than 1 year. First-line treatment 

 was more common with ranibizumab (55% of patients) than with 

 aflibercept (30%), or dexamethasone implant (15%). About 25% 

 of patients who initiated anti-VEGF treatment switched treatment 

 at least once, while 30% of patients who initiated 

 dexamethasone implant switched to anti-VEGF treatment at least 

 once. CONCLUSIONS: French DME patients seem well-monitored by 

 their ophthalmologist, but median DME treatment duration was 

 just 9 months. These results emphasise the challenge to manage 

 and treat patients with DME over the long term.},

keywords = {anti-VEGF; diabetic macular oedema; management; real-world;   treatment},

pubstate = {published},

tppubtype = {article}

}

@article{Creuzot_Garcher2023-bx,

title = {Management of neovascular age-related macular degeneration 

 treatment in France from 2008-2018: The nationwide LANDSCAPE 

 study},

author = {Catherine P Creuzot Garcher and Mayer Srour and Florian Baudin and Corinne Dot and Sylvia Nghiem-Buffet and Jean-Francois Girmens and Cedric Collin and Anne Ponthieux and Cécile Delcourt},

year  = {2023},

date = {2023-10-01},

journal = {Ophthalmol. Ther.},

volume = {12},

number = {5},

pages = {2687–2701},

abstract = {INTRODUCTION: The aim of this study was to describe the 

 management of neovascular age-related macular degeneration (nAMD) 

 in French patients between 2008 and 2018. METHODS: This was a 

 retrospective longitudinal cohort study using exhaustive 

 nationwide health records from the French National Health 

 Information database. Enrollment criteria were adults aged $geq$ 

 50 years, nAMD diagnosis, or reimbursement for nAMD treatments 

 (anti-vascular epithelial growth factor [VEGF] injection or 

 dynamic phototherapy with verteporfin). Exclusion criteria were 

 high myopia, diagnosis of other retinal diseases, and treatments 

 for other macular diseases (dexamethasone implant, laser). Main 

 outcome measures were consumption of medical care and nAMD 

 treatments per calendar year and number of years of follow-up. 

 RESULTS: Between 2008 and 2018, we identified 342,961 patients 

 who have been treated for nAMD. Median duration of 

 ophthalmological follow-up exceeded 7 years (90 months). The 

 median annual number of ophthalmology consultations decreased 

 from nine visits in year 1 after treatment initiation to four 

 visits from year 7 onwards. The median duration of nAMD treatment 

 was 10.1 months for all patients, with 48.5% of patients 

 undergoing treatment for < 1 year. Only 24.4% of patients had 

 maintained treatment at year 11. Patients remaining under 

 treatment had a median of four anti-VEGF treatments per year 

 throughout the 10-year study period. Ranibizumab was the more 

 common first-line treatment (67.5% of patients) compared to 

 aflibercept (32.4%). About 20% of patients who initiated 

 treatment switched treatment at least once. CONCLUSIONS: 

 LANDSCAPE provides exhaustive nationwide data on the real-world 

 management of nAMD in France over a 10-year period. Further 

 investigation into short treatment duration is required, 

 especially in terms of understanding its relation to visual 

 outcomes.},

keywords = {Anti-VEGF; Neovascular age-related macular degeneration;   Real-world management; Syst{è}me National des Donn{é}es de   Sant{é}},

pubstate = {published},

tppubtype = {article}

}

@article{Baudin2023-gs,

title = {Impact of COVID-19 lockdown on surgical procedures for retinal 

 detachment in France: a national database study},

author = {Florian Baudin and Eric Benzenine and Anne-Sophie Mariet and Inès Ben Ghezala and Vincent Daien and Pierre-Henry Gabrielle and Catherine Quantin and Catherine P Creuzot-Garcher},

year  = {2023},

date = {2023-04-01},

journal = {Br. J. Ophthalmol.},

volume = {107},

number = {4},

pages = {565–569},

publisher = {BMJ},

abstract = {BACKGROUND/AIMS: The COVID-19 crisis and the decisions made 

 regarding population lockdown may have changed patient care. We 

 aimed to investigate the incidence rate of rhegmatogenous 

 retinal detachment (RRD) cases during the COVID-19 lockdown 

 period. METHODS: In this nationwide database study, we 

 identified hospital and clinic admissions of French residents 

 for a first episode of RRD in France from 2017 to the lockdown 

 period in 2020. The monthly hospital incidence rates of RRD 

 procedures per 100 000 inhabitants before, during and after 

 lockdown were computed for the whole country. Finally, we 

 assessed the influence of viral incidence on the RRD incidence 

 rate, comparing two regions with highly contrasting viral 

 penetration. RESULTS: From January to July, the average monthly 

 national hospital incidence rate of RRD decreased from a mean of 

 2.59/100 000 inhabitants during 2017-2019 to 1.57/100 000 

 inhabitants in 2020. Compared with 2019, during the 8-week 

 lockdown period in 2020, a 41.6% decrease in the number of RRD 

 procedures was observed (p<0.001) with the weekly incidence of 

 RRD decreasing from 0.63/100 000 inhabitants in 2019 to 0.36/100 

 000 inhabitants. During the 4-month post-lockdown period, no 

 increased activity related to postponed procedures was observed. 

 No difference was found in the rate of RRD surgery when 

 comparing two regions with highly contrasting viral incidence. 

 CONCLUSION: Containment may have been responsible for a decrease 

 in the number of surgical procedures for RRD, without any 

 compensating post-lockdown activity in France. These results 

 might help increase awareness of the management of RRD 

 emergencies.},

keywords = {COVID-19; epidemiology; retina},

pubstate = {published},

tppubtype = {article}

}

@article{Hurand2023-gc,

title = {IMPACT study: Impact of adherence to anti-VEGF intravitreal 

 injections for macular disease during COVID 19-related 

 confinement in France},

author = {Victoire Hurand and Jean-Baptiste Ducloyer and Florian Baudin and Serge Aho and Michel Weber and Laurent Kodjikian and François Devin and Pierre-Henry Gabrielle and Catherine Creuzot-Garcher and Pascale Massin and CFSR Research Net},

year  = {2023},

date = {2023-02-01},

journal = {Acta Ophthalmol.},

volume = {101},

number = {1},

pages = {91–99},

publisher = {Wiley},

abstract = {PURPOSE: The aim of this study was to evaluate the impact of 

 adherence to French coronavirus disease 2019 (COVID 19)-related 

 guidelines for intravitreal injection (IVI) practice on the 

 visual outcomes of patients treated with anti-vascular 

 endothelial growth factor (VEGF) agents for macular diseases 

 during the first lockdown period. METHODS: Observational 

 multicentre study including all patients from 18 centres with an 

 IVI initially planned during the lockdown. Visual acuity (VA, 

 ETDRS) was recorded at 1 and 4 months after lockdown. French 

 COVID 19-related guidelines recommended maintaining IVI 

 practice. We defined three groups of patients: A, adherent to 

 guidelines; NA+, non-adherent with delayed IVIs; and NA-, 

 non-adherent without IVIs performed during the lockdown. Risk 

 factors for non-adherence and visual loss were studied. RESULTS: 

 A total of 3020 eyes of 3020 patients, aged 77.8 $±$ 11.6 

 years, 59.8% women, were included. 59.3% were 

 non-adherent(46.7% NA+, 12.6% NA-). A smaller decrease in VA 

 at 4 months was observed in the A group than the NA+ and NA- 

 group (-0.2 $±$ 6.7, -0.3 $±$ 6.9 and -1.5 $±$ 6.9, 

 respectively [p < 0.001]). Factors associated with non-adherence 

 were in multivariable analysis, older age, hospital practice, 

 low-density population areas, high viral incidence areas, longer 

 intervals between injection and treat and extent protocol. 

 Factors associated with visual loss at 4 months in multivariable 

 analysis were, being in the NA- group, older age, T&E and fixed 

 regimens. CONCLUSION: Strict adherence to guidelines was 

 associated with better visual outcome, although most of our 

 patients did not attend as planned. Identification of patients 

 at risk could help in the future in case of a new pandemic 

 lockdown.},

keywords = {COVID-19; intravitreal injection; nAMD; visual acuity},

pubstate = {published},

tppubtype = {article}

}

@article{Carre2023-te,

title = {Effects of topical docosahexaenoic acid on postoperative 

 fibrosis in an animal model of glaucoma filtration surgery},

author = {Chloé Carré and Florian Baudin and Bénédicte Buteau and Lucy Martine and Stéphane Grégoire and Glenda Vasku and Olivier Berdeaux and Arnaud Béduneau and Yann Pellequer and Jasmine Jamoussi and Catherine Desrumeaux and Serge Aho and Alain-Marie Bron and Niyazi Acar and Catherine Creuzot-Garcher and Pierre Henri Gabrielle},

year  = {2023},

date = {2023-02-01},

journal = {Acta Ophthalmol.},

volume = {101},

number = {1},

pages = {e61–e68},

publisher = {Wiley},

abstract = {PURPOSE: The aim of this study was to evaluate docosahexaenoic 

 acid (DHA) as a potential antifibrotic agent after glaucoma 

 filtration surgery (GFS) in rats. METHODS: A total of 36 

 10-week-old Brown Norway rats underwent GFS. Animals were 

 equally divided into three groups: a control group, a DHA group 

 and a mitomycin C (MMC) group. Intraocular pressure (IOP) was 

 measured using a dynamic rebound tonometer, and a photograph of 

 the surgical site was taken on days 1, 3, 7, 10, 14 and 17. The 

 incorporation of DHA into fibroblasts was evaluated by gas 

 chromatography. The expression of alfa-smooth muscle actin 

 (α-SMA) and Smad proteins was assessed by Western 

 blotting. RESULTS: IOP decreased after surgery in animals from 

 the three groups on day 1 after surgery. Over time, IOP remained 

 lower in the DHA and MMC groups than in the control group 

 (median [interquartile range] 8.0 [7.0-8.0] and 8.0 [7.3-8.0] 

 mmHg vs. 9.0 [8.0-9.0] mmHg, respectively; p < 0.001). Bleb area 

 in the DHA and MMC groups remained larger than that of the 

 control group from day 7 to day 14 (3.9 [2.9-5.2] and 3.5 [2.3-4.4] mm2 vs. 2.3 [2.0-2.8] mm2 , respectively; p = 0.0021). 

 We did not observe any change in DHA concentrations in the 

 fibroblasts of the DHA group compared with the other groups. 

 CONCLUSION: The impact of DHA on IOP and bleb area was similar 

 to that of MMC. The mechanisms of action of DHA in rat eye 

 fibroblasts deserve further investigation.},

keywords = {docosahexaenoic acid; fibrosis; glaucoma; glaucoma surgery},

pubstate = {published},

tppubtype = {article}

}

@article{Ben_Ghezala2022-nl,

title = {Incidence of rhegmatogenous retinal detachment following macular 

 surgery in France between 2006 and 2016},

author = {Inès Ben Ghezala and Anne-Sophie Mariet and Eric Benzenine and Pierre-Henry Gabrielle and Florian Baudin and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-11-01},

journal = {Am. J. Ophthalmol.},

volume = {243},

pages = {91–97},

publisher = {Elsevier BV},

abstract = {PURPOSE: To report the incidence of postoperative rhegmatogenous 

 retinal detachment after macular surgery in France between 2006 

 and 2016, and identify associated factors. DESIGN: Nationwide, 

 population-based, cohort study. METHODS: All surgical procedures 

 for an epiretinal membrane or a macular hole performed in France 

 from January 1, 2006 to October 31, 2016 were identified in the 

 French national administrative database (Programme de 

 Médicalisation des Systèmes d'Information). The 

 incidence of rhegmatogenous retinal detachment occurring within 

 90 days of a macular surgical procedure was investigated. 

 RESULTS: From January 1, 2006 to October 31, 2016, 152,034 

 macular surgical procedures for epiretinal membranes or macular 

 holes were recorded in France. Of these, 3605 cases of 

 rhegmatogenous retinal detachment occurring within 90 days of 

 the procedure were found. The incidence of rhegmatogenous 

 retinal detachment was 2.37% overall, 1.95% for epiretinal 

 membrane surgery, and 3.43% for macular hole surgery. In 

 multivariable Poisson regression analysis, rhegmatogenous 

 retinal detachment was associated with macular hole surgery 

 (incidence rate ratio [IRR], 1.76; 95% CI, 1.63-1.90; P < 

 .001), history of cataract extraction in the previous year (IRR, 1.20; 95% CI, 1.08-1.34; P = .001), age <60 years (P < .001), 

 and male sex (IRR, 1.63; 95% CI, 1.51-1.76; P < .001). 

 CONCLUSIONS: The incidence of rhegmatogenous retinal detachment 

 within 90 days of macular surgery was 2.37% overall in France 

 between 2006 and 2016, and it was higher for macular hole 

 surgery than for epiretinal membrane surgery.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ben_Ghezala2022-vy,

title = {Incidence of rhegmatogenous retinal detachment following macular 

 surgery in France between 2006 and 2016},

author = {Inès Ben Ghezala and Anne-Sophie Mariet and Eric Benzenine and Pierre-Henry Gabrielle and Florian Baudin and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-11-01},

journal = {Am. J. Ophthalmol.},

volume = {243},

pages = {91–97},

publisher = {Elsevier BV},

abstract = {PURPOSE: To report the incidence of postoperative rhegmatogenous 

 retinal detachment after macular surgery in France between 2006 

 and 2016, and identify associated factors. DESIGN: Nationwide, 

 population-based, cohort study. METHODS: All surgical procedures 

 for an epiretinal membrane or a macular hole performed in France 

 from January 1, 2006 to October 31, 2016 were identified in the 

 French national administrative database (Programme de 

 Médicalisation des Systèmes d'Information). The 

 incidence of rhegmatogenous retinal detachment occurring within 

 90 days of a macular surgical procedure was investigated. 

 RESULTS: From January 1, 2006 to October 31, 2016, 152,034 

 macular surgical procedures for epiretinal membranes or macular 

 holes were recorded in France. Of these, 3605 cases of 

 rhegmatogenous retinal detachment occurring within 90 days of 

 the procedure were found. The incidence of rhegmatogenous 

 retinal detachment was 2.37% overall, 1.95% for epiretinal 

 membrane surgery, and 3.43% for macular hole surgery. In 

 multivariable Poisson regression analysis, rhegmatogenous 

 retinal detachment was associated with macular hole surgery 

 (incidence rate ratio [IRR], 1.76; 95% CI, 1.63-1.90; P < 

 .001), history of cataract extraction in the previous year (IRR, 1.20; 95% CI, 1.08-1.34; P = .001), age <60 years (P < .001), 

 and male sex (IRR, 1.63; 95% CI, 1.51-1.76; P < .001). 

 CONCLUSIONS: The incidence of rhegmatogenous retinal detachment 

 within 90 days of macular surgery was 2.37% overall in France 

 between 2006 and 2016, and it was higher for macular hole 

 surgery than for epiretinal membrane surgery.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Baudin2022-mg,

title = {Topical antibiotic prophylaxis and intravitreal injections: 

 Impact on the incidence of acute endophthalmitis-A nationwide 

 study in France from 2009 to 2018},

author = {Florian Baudin and Eric Benzenine and Anne-Sophie Mariet and Inès Ben Ghezala and Alain M Bron and Vincent Daien and Pierre-Henry Gabrielle and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-10-01},

journal = {Pharmaceutics},

volume = {14},

number = {10},

pages = {2133},

publisher = {MDPI AG},

abstract = {Background: The dramatic increase in intravitreal injections 

 (IVTs) has been accompanied by a greater need for safer 

 procedures. The ongoing debate about topical antibiotic 

 prophylaxis after IVTs emphasizes the importance of large-scale 

 studies. We aimed to study the role of topical antibiotic 

 prophylaxis in reducing the risk of acute endophthalmitis after 

 IVTs. Methods: Population-based cohort study, in France, from 

 2009 to 2018, including all French patients receiving IVTs of 

 corticosteroids or anti-VEGF agents. Results: A total of 

 5,291,420 IVTs were performed on 605,434 patients. The rate of 

 topical antibiotic prophylaxis after IVTs progressively 

 decreased during the study period, with a sharp drop in 2014 

 (from 84.6% in 2009 to 27.4% in 2018). Acute endophthalmitis occurred in 1274 cases (incidence rate = 0.0241%). Although 

 antibiotic prophylaxis did not alter the risk of endophthalmitis (p = 0.06), univariate analysis showed an increased risk after 

 fluoroquinolone and aminoglycoside prophylaxis. This increased 

 risk was not found in multivariate analysis. However, we 

 observed an increased risk related to the use of fixed 

 combinations of fluoroquinolones and aminoglycosides with corticosteroids (IRR = 1.89; 95% CI = 1.57-2.27%, antibiotics 

 combined with corticosteroids). Conclusion: These results are 

 consistent with the literature. Endophthalmitis rates after IVTs 

 did not decrease with topical antibiotic prophylaxis. The use of 

 a combination of antibiotics and corticosteroids doubles the 

 risk of endophthalmitis and should be avoided. Avoiding 

 antibiotic prophylaxis would reduce the costs and the potential 

 risks of antibiotic resistance.},

keywords = {IVT; antibiotics; endophthalmitis; intravitreal injection},

pubstate = {published},

tppubtype = {article}

}

@article{Creuzot-Garcher2022-ro,

title = {Epidemiology of treated diabetes ocular complications in France 

 2008-2018-the LANDSCAPE French nationwide study},

author = {Catherine Creuzot-Garcher and Pascale Massin and Mayer Srour and Florian Baudin and Corinne Dot and Sylvia Nghiem-Buffet and Jean-Francois Girmens and Cedric Collin and Anne Ponthieux and Cecile Delcourt},

year  = {2022},

date = {2022-10-01},

journal = {Pharmaceutics},

volume = {14},

number = {11},

pages = {2330},

publisher = {MDPI AG},

abstract = {AIM: LANDSCAPE aimed to estimate the annual incidence and 

 prevalence of treated diabetic macular edema (DME) and 

 proliferative diabetic retinopathy (PDR) between 2008 and 2018. 

 METHODS: This French nationwide observational study used data 

 from the French National Health Insurance Databases covering 

 99% of the French population. Data about healthcare consumption 

 were used to identify adults treated with anti-VEGFs or 

 dexamethasone implants (for DME) and with pan-retinal 

 photocoagulation (for PDR). All French patients newly treated 

 between 2008 and 2018 were included. Incidence and prevalence of 

 treated DME and PDR were estimated for the age-matched general 

 population and the population with diabetes in France. 

 Sociodemographic characteristics and medical history were 

 described in both populations. RESULTS: We identified 53,584 

 treated DME patients and 127,273 treated PDR patients between 

 2008 and 2018, and 11,901 DME and 11,996 PDR new incident 

 patients in 2018. The treated DME incidence in 2018 was 2.5 per 

 10,000 in the general population and 37.3 per 10,000 in the 

 population with diabetes. Prevalence in 2018 was 9.5 and 143.7 

 per 10,000 in the respective populations. Treated PDR incidence 

 in 2018 was 2.3 per 10,000 in the general population and 31.2 

 per 10,000 in the population with diabetes. Prevalence in 2018 

 was 19.9 and 270.3 per 10,000 in the respective populations. 

 Incidence and prevalence were not age-dependent. Incidence of 

 treated PDR incidence was relatively stable from 2008-2018. 

 Incidence of treated DME incidence rose from 2012-2018, probably 

 due to widening access to newly available treatments, such as 

 anti-VEGFs. CONCLUSIONS: We provide exhaustive nationwide data 

 on the incidence and prevalence of treated diabetic ocular 

 complications in France over a 10-year period.},

keywords = {France; diabetic macular edema; diabetic retinopathy; drug   consumption; incidence; nationwide study; prevalence},

pubstate = {published},

tppubtype = {article}

}

@article{Ben_Ghezala2022-ir,

title = {Association between obstetric complications and intravitreal 

 anti-vascular endothelial growth factor agents or intravitreal 

 corticosteroids},

author = {Inès Ben Ghezala and Anne-Sophie Mariet and Eric Benzenine and Marc Bardou and Alain Marie Bron and Pierre-Henry Gabrielle and Florian Baudin and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-08-01},

journal = {J. Pers. Med.},

volume = {12},

number = {9},

pages = {1374},

publisher = {MDPI AG},

abstract = {This nationwide population-based cohort study aimed to describe 

 the use of intravitreal injections (IVTs) of anti-vascular 

 endothelial growth factor (anti-VEGF) agents and corticosteroids 

 in pregnant women in France and to report on the incidence of 

 obstetric and neonatal complications. All pregnant women in 

 France who received any anti-VEGF or corticosteroid IVT during 

 pregnancy or in the month preceding pregnancy from 1 January 

 2009 to 31 December 2018 were identified in the national 

 medico-administrative databases. Between 2009 and 2018, there 

 were 5,672,921 IVTs performed in France. Among these IVTs, 228 

 anti-VEGF or corticosteroid IVTs were administered to 139 women 

 during their pregnancy or in the month preceding their 

 pregnancy. Spontaneous abortion or the medical termination of 

 pregnancy occurred in 10 women (16.1%) who received anti-VEGF 

 agents and in one (3.1%) of the women who received corticosteroids (p = 0.09). This is the first national cohort 

 study of pregnant women treated with anti-VEGF or corticosteroid 

 IVTs. We found a high incidence of obstetric complications in 

 pregnant women treated with anti-VEGF or corticosteroid IVTs but 

 could not demonstrate a statistically significant association 

 between the intravitreal agents and these complications. These 

 agents should continue to be used with great caution in pregnant 

 women.},

keywords = {anti-vascular endothelial growth factor; corticosteroid; drug   safety; intravitreal injection; obstetric complication;   pharmacoepidemiology; pregnancy},

pubstate = {published},

tppubtype = {article}

}

@article{Ben_Ghezala2022-xr,

title = {Incidence of rhegmatogenous retinal detachment in France from 

 2010 to 2016: seasonal and geographical variations},

author = {Inès Ben Ghezala and Anne Sophie Mariet and Eric Benzenine and Pierre-Henry Gabrielle and Florian Baudin and Alain M Bron and Catherine Quantin and Catherine P Creuzot-Garcher},

year  = {2022},

date = {2022-08-01},

journal = {Br. J. Ophthalmol.},

volume = {106},

number = {8},

pages = {1093–1097},

abstract = {AIMS: To investigate the annual and monthly hospital incidence 

 rate of rhegmatogenous retinal detachments (RRDs) from 2010 to 

 2016 in France at the national and regional levels. METHODS: In 

 this nationwide database study, we identified hospital and clinic 

 admissions of French residents for a first episode of RRD in 

 France during 2010-2016 from the national administrative 

 database. The annual and monthly hospital incidence rates of RRD 

 per 100 000 population were calculated for the whole country and 

 for each region. RESULTS: The average annual national hospital 

 incidence rate of RRD was 21.97$±$1.04 per 100 000 population. 

 The annual national hospital incidence rate of RRD was the lowest 

 in 2010 (20.91 per 100 000 population) after which it increased 

 until 2015 (23.55 per 100 000 population). The average monthly 

 national RRD hospital incidence rate was the highest in June 

 (2.03$±$0.12 per 100 000 population) and the lowest in August 

 (1.60$±$0.09). The average annual age-standardised and 

 sex-standardised regional hospital incidence rate was the highest 

 in Guadeloupe and Pays de la Loire (28.30$±$2.74 and 

 26.13$±$0.84 per 100 000 population, respectively) and the 

 lowest in French Guiana and Martinique (15.51$±$3.50 and 

 17.29$±$2.12 per 100 000 population, respectively). 

 CONCLUSIONS: The average annual national hospital incidence rate 

 of RRD increased from 2010 to 2015. The hospital incidence rate 

 of RRD seemed to vary according to season and geographical 

 location.},

keywords = {epidemiology; retina; treatment surgery},

pubstate = {published},

tppubtype = {article}

}

@article{Merad2022-my,

title = {Cystoid macular edema after rhegmatogenous retinal detachment 

 repair with pars Plana vitrectomy: Rate, risk factors, and 

 outcomes},

author = {Malik Merad and Fabien Vérité and Florian Baudin and Inès Ben Ghezala and Cyril Meillon and Alain Marie Bron and Louis Arnould and Pétra Eid and Catherine Creuzot-Garcher and Pierre-Henry Gabrielle},

year  = {2022},

date = {2022-08-01},

journal = {J. Clin. Med.},

volume = {11},

number = {16},

pages = {4914},

publisher = {MDPI AG},

abstract = {(1) Background: The aim was to describe the rate and outcomes of 

 cystoid macular edema (CME) after pars plana vitrectomy (PPV) 

 for primary rhegmatogenous retinal detachment (RRD) and to 

 identify risk factors and imaging characteristics. (2) Methods: 

 A retrospective consecutive case study was conducted over a 

 5-year period among adult patients who underwent PPV for primary 

 RRD repair. The main outcome measure was the rate of CME at 12 

 months following PPV. (3) Results: Overall, 493 eyes were 

 included. The CME rate was 28% (93 patients) at 12 months. In 

 multivariate analysis, eyes with worse presenting visual acuity (VA) (odds ratio [OR], 1.55; 95% CI, 1.07-2.25; p = 0.02) and 

 grade C proliferative vitreoretinopathy (PVR) (OR, 2.88; 95% CI, 1.04-8.16; p = 0.04) were more at risk of developing CME 1 

 year after PPV. Endolaser retinopexy was associated with a 

 greater risk of CME than cryotherapy retinopexy (OR, 3.06; 95% CI, 1.33-7.84; p = 0.01). Eyes undergoing cataract surgery 

 within 6 months of the initial RRD repair were more likely to develop CME at 12 months (OR, 1.96; 95% CI, 1.06-3.63; p = 

 0.03). (4) Conclusions: CME is a common complication after PPV 

 for primary RRD repair. Eyes with worse presenting VA, severe 

 PVR at initial presentation, endolaser retinopexy, and cataract 

 surgery within 6 months of initial RRD repair were risk factors 

 for postoperative CME at 12 months.},

keywords = {cystoid macular edema; pars plana vitrectomy; rhegmatogenous   retinal detachment; spectral-domain optical coherence   tomography; vitreoretinal surgery},

pubstate = {published},

tppubtype = {article}

}

@article{Arnould2022-jn,

title = {Repeatability and reproducibility of retinal fractal dimension 

 measured with swept-source optical coherence tomography 

 angiography in healthy eyes: A proof-of-concept study},

author = {Louis Arnould and Déa Haddad and Florian Baudin and Pierre-Henry Gabrielle and Marc Sarossy and Alain M Bron and Behzad Aliahmad and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-07-01},

journal = {Diagnostics (Basel)},

volume = {12},

number = {7},

pages = {1769},

publisher = {MDPI AG},

abstract = {The retinal vascular network fractal dimension (FD) could be a 

 promising imaging biomarker. Our objective was to evaluate its 

 repeatability and reproducibility in healthy eyes. A 

 cross-sectional study was undertaken with young, healthy 

 volunteers who had no reported cardiac risk factors or ocular 

 disease history. For each participant, three SS-OCTA images (12 

 $times$ 12 mm) were acquired using the Plex Elite 9000 (Carl 

 Zeiss Meditec AG, Jena, Germany) by two ophthalmologists. 

 Automated segmentation was obtained from both the superficial 

 and deep capillary plexuses. FD was estimated by box counting. 

 The intraclass correlation coefficients (ICC) were used as 

 measures for repeatability and reproducibility. A total of 43 

 eyes of healthy volunteers were included. The mean $±$ 

 standard deviation (SD) age was 30 $±$ 6.2 years. The results 

 show good repeatability. The ICC was 0.722 (95% CI, 

 0.541-0.839) in the superficial capillary plexus and 0.828 (95% 

 CI, 0.705-0.903) in the deep capillary plexus. For 

 reproducibility, the ICC was 0.651 (95% CI, 0.439-0.795) and 

 0.363 (95% CI, 0.073-0.596) at the superficial and deep 

 capillary plexus, respectively. In this study, the FD of the 

 vascular network measured via SS-OCTA showed good repeatability 

 and reproducibility in healthy participants.},

keywords = {deep retinal capillary plexus; fractal dimension; healthy   volunteers; retina; superficial retinal capillary plexus;   swept-source OCT angiography; vascular imaging},

pubstate = {published},

tppubtype = {article}

}

@article{Ducray2022-mg,

title = {Syndrome de fluide dans l'interface secondaire à un 

 traumatisme contusif chez un patient aux antécédents de 

 chirurgie réfractive par femtoLASIK},

author = {V Ducray and F Baudin and Q Bosredon and V Theillac and C Creuzot-Garcher and L Arnould},

year  = {2022},

date = {2022-06-01},

journal = {J. Fr. Ophtalmol.},

volume = {45},

number = {6},

pages = {e265–e267},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Chauvet2022-ob,

title = {Arthroscopic Trillat technique for chronic post-traumatic 

 anterior shoulder instability: outcomes at 2 years of follow-up},

author = {Thomas Chauvet and Ludovic Labattut and Romain Colombi and Florian Baudin and Emmanuel Baulot and Pierre Martz},

year  = {2022},

date = {2022-06-01},

journal = {J. Shoulder Elbow Surg.},

volume = {31},

number = {6},

pages = {e270–e278},

publisher = {Elsevier BV},

abstract = {BACKGROUND: The purpose of this study was to assess the outcomes 

 of a new arthroscopic Trillat technique at a 2-year follow-up. 

 Our current hypothesis was that this technique could be used for 

 the effective treatment of chronic post-traumatic unidirectional 

 anterior shoulder instability, and that the recurrence and 

 complication rates, external rotation, and functional outcomes 

 would be as good as those of the reference technique. METHODS: 

 Between April 2012 and August 2016, all patients older than 16 

 years who underwent the arthroscopic Trillat technique for 

 unidirectional chronic post-traumatic anterior shoulder 

 instability at the Dijon University Hospital (France), after the 

 failure of well-conducted medical and rehabilitation treatment 

 with at least 24 months of follow-up, were included. Criteria 

 for noninclusion were association with posterior and/or inferior 

 instabilities, voluntary instabilities, and glenoid bone loss 

 greater than 20%. Patients attended follow-up with their 

 surgeon before the intervention, in the immediate postoperative 

 period, at 6 weeks, 3 and 6 months, and then by an independent 

 observer for the last evaluation. Patients were then examined 

 clinically with scores such as Constant, Rowe and Walch-Duplay 

 scores, and subjective shoulder value, for shoulder range of 

 motion, and radiographically (anteroposterior and Lamy's lateral 

 x-rays of the operated shoulder). RESULTS: Forty-nine patients 

 and 52 shoulders were included, with a mean follow-up of 40 

 months (range, 24-71 months). The recurrence rate of instability 

 was 3.8% (2 of 52). No conversion to arthrotomy was necessary. 

 No intraoperative complications, postoperative neurological 

 lesions, or sepsis were observed. The mean Constant score was 

 92.1 (77.5-100) points, Walch-Duplay 82.9 (40-100), Rowe 81.73 

 (5-100), and subjective shoulder value 86.1 (50-100) at the last 

 follow-up. The arm at side external rotation limitation averaged 

 8.4° (-25° to 40°) and the external rotation with 90° arm 

 abduction limitation 0.34° (-5° to 15°). Forty-one patients 

 (79%) resumed their sports activity at the same level. Fifty 

 patients (96%) were satisfied to very satisfied. One patient 

 developed nonunion of the coracoid process and subsequently 

 underwent a Latarjet procedure with a good outcome. CONCLUSIONS: 

 The arthroscopic Trillat procedure offers good outcomes as a 

 first-line treatment for chronic anterior post-traumatic 

 glenohumeral instability. It should be excluded in cases of 

 glenoid loss greater than 20%.},

keywords = {Shoulder; Trillat; arthroscopy; bone block; conjoined tendon;   instability},

pubstate = {published},

tppubtype = {article}

}

@article{Baudin2022-es,

title = {Epidemiology of acute endophthalmitis after intraocular 

 procedures: A national database study},

author = {Florian Baudin and Eric Benzenine and Anne-Sophie Mariet and Inès Ben Ghezala and Alain M Bron and Vincent Daien and Jean François Korobelnik and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-06-01},

journal = {Ophthalmol. Retina},

volume = {6},

number = {6},

pages = {442–449},

publisher = {Elsevier BV},

abstract = {OBJECTIVE: To describe the causes of postoperative acute 

 endophthalmitis at the national level longitudinally. DESIGN: 

 Cohort study from 2009 to 2018 in France. PARTICIPANTS: Patients 

 diagnosed with acute endophthalmitis after intraocular 

 procedures. METHODS: The French medical-administrative database 

 was used. Endophthalmitis cases and intraocular procedures were 

 identified based on billing codes in all French hospitals and 

 private practices. MAIN OUTCOME MEASURES: The incidence of acute 

 endophthalmitis within 42 days of the procedure. RESULTS: From 

 January 1, 2009, to October 31, 2018, 7522 cases of acute 

 endophthalmitis occurred after 14 438 854 intraocular 

 procedures. Most cases occurred after standalone cataract 

 surgery (4808 cases for 7 316 077 procedures; 63.92%), followed 

 by after intravitreal (IVT) injections (1296 cases for 5 455 631 

 IVT injections; 17.23%), vitreoretinal surgery (698 for 442 263 

 procedures; 9.28%), anterior segment surgery (245 cases; 

 3.26%), combined cataract and vitreoretinal surgery (191 cases; 

 2.54%), cornea surgery (142 cases; 1.89%), and glaucoma 

 surgery (80 cases; 1.06%). The overall incidence of acute 

 endophthalmitis was 1 per 1920 procedures (0.0521%; 95% 

 confidence interval [CI], 0.0520-0.0522). The surgery with the 

 highest incidence of endophthalmitis was scleral and globe 

 surgery, with an incidence of 0.1827% (95% CI, 0.1757-0.1898), 

 followed by vitreoretinal surgery combined with cataract 

 surgery, with an incidence of 0.1685% (95% CI, 0.1663-0.1706). 

 The incidence of endophthalmitis after IVT injections was stable 

 over the study period, and patients receiving IVT injections 

 were the oldest, aged 75.4 years (standard deviation, 12.0 

 years; P < 0.001). The onset of endophthalmitis after IVT 

 procedures, i.e, after receiving IVT injections or undergoing 

 vitreoretinal surgery, was earlier than that after the other 

 procedures (P < 0.001). CONCLUSIONS: The profile of patients 

 referred for acute endophthalmitis has been evolving over the 

 past decade, with a decrease in the raw number of 

 endophthalmitis cases after cataract surgery as opposed to an 

 increase in the number of patients presenting with 

 endophthalmitis after IVT injections.},

keywords = {Endophthalmitis; Epidemiology; National database},

pubstate = {published},

tppubtype = {article}

}

@article{Seydou2022-es,

title = {Plasma fatty acids pattern and dry eye disease in the elderly: 

 The Montrachet population-based study},

author = {Alassane Seydou and Louis Arnould and Pierre-Henry Gabrielle and Florian Baudin and Ines Ben Ghezala and Alain M Bron and Niyazi Acar and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-05-01},

journal = {Nutrients},

volume = {14},

number = {11},

pages = {2290},

publisher = {MDPI AG},

abstract = {(1) Background: To investigate the association between plasma 

 fatty acids (FAs) and dry eye disease (DED) in an elderly 

 population; (2) Methods: We conducted a population-based study, 

 the Montrachet study, in individuals older than 75 years. DED 

 was evaluated using the Schirmer I test without anesthesia, tear 

 film breakup time (TFBUT) measurement and fluorescein corneal 

 staining. Plasma FAs were measured in fasting blood using gas 

 chromatography; (3) Results: A total of 740 subjects with a 

 plasma measurement of 25 FAs were included in this study. The 

 mean age was 82.2 $±$ 3.7 years, and 62.7% were women. DED 

 was present in 35.0% of participants. We identified a plasma 

 FAs pattern positively associated with DED, characterized by low 

 polyunsaturated fatty acids (PUFAs), high monounsaturated fatty 

 acids (MUFAs) and low saturated fatty acids (SFAs) levels. After 

 adjustment for major confounders, individuals in the upper 

 quartile of the FAs pattern scores compared with those in the 

 lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51-4.01},

keywords = {dry eye disease; elderly; epidemiology; fatty acids pattern;   lipids; ocular surface; population-based study},

pubstate = {published},

tppubtype = {article}

}

@article{Gabrielle2022-go,

title = {Bilateral acute macular neuroretinopathy in a young woman after 

 the first dose of Oxford-AstraZeneca COVID-19 vaccine},

author = {Pierre-Henry Gabrielle and Florian Baudin and Ines Ben Ghezala and Cyril Meillon and Alain Marie Bron and Louis Arnould and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-03-01},

journal = {Am. J. Ophthalmol. Case Rep.},

volume = {25},

number = {101281},

pages = {101281},

publisher = {Elsevier BV},

abstract = {PURPOSE: To report a case of bilateral acute macular 

 neuroretinopathy following the first dose of Oxford-AstraZeneca 

 COVID-19 (coronavirus disease 2019) vaccine in a young, 

 Caucasian, and healthy woman. OBSERVATIONS: A 25-year-old 

 Caucasian female patient presented to the ophthalmology 

 department of Dijon University Hospital with a 3-week history of 

 black spots and paracentral scotoma in both eyes. She had no 

 past medical history and was using the combined 

 estrogen-progestin oral contraceptive (COC). These symptoms 

 occurred 24 h after receiving the first Oxford-AstraZeneca 

 COVID-19 vaccination dose. The ophthalmologic signs were 

 preceded a few hours earlier by fever and flu-like symptoms. 

 Ophthalmologic examination revealed a preserved visual acuity 

 with a quiet anterior segment and normal fundus in both eyes. 

 Findings on multimodal retinal imaging, particularly 

 near-infrared reflectance (NIR) and optical coherence tomography 

 (OCT) imaging, were classical of an acute macular 

 neuroretinopathy in both eyes. CONCLUSIONS AND IMPORTANCE: 

 COVID-19 vaccination is justified as an essential public health 

 measure. Acute macular neuroretinopathy may occur in patient 

 receiving a COVID-19 vaccination dose. Further reports are 

 needed to confirm this association. Physicians should be aware 

 of this complication and request an eye examination with at 

 least OCT or NIR imaging in the case of any visual symptoms 

 after vaccination, notably in young women using COC.},

keywords = {AMN; Acute macular neuroretinopathy; COVID-19; Side effect;   Vaccination},

pubstate = {published},

tppubtype = {article}

}

@article{Creuzot-Garcher2022-mg,

title = {Incidence and prevalence of neovascular age-related macular 

 degeneration in France between 2008 and 2018: The LANDSCAPE 

 study},

author = {Catherine P Creuzot-Garcher and Mayer Srour and Florian Baudin and Vincent Daien and Corinne Dot and Sylvia Nghiem-Buffet and Jean-Francois Girmens and Nicolas Coulombel and Anne Ponthieux and Cecile Delcourt},

year  = {2022},

date = {2022-03-01},

journal = {Ophthalmol. Sci.},

volume = {2},

number = {1},

pages = {100114},

publisher = {Elsevier BV},

abstract = {Purpose: This study aimed to estimate the incidence and 

 prevalence of neovascular age-related macular degeneration 

 (nAMD) in the French population between 2008 and 2018. Design: 

 This was a retrospective, longitudinal population study using 

 health care consumption data from the Système National des 

 Données de Santé (SNDS; the French National Health 

 Information Database), which covers approximately 99% of the 

 French population. Participants: We identified individuals 

 treated for nAMD from the French population 50 years of age and 

 older. Identification criteria were nAMD diagnosis or 

 reimbursement of nAMD treatments (anti-vascular endothelial 

 growth factor intravitreal injection or dynamic phototherapy 

 with verteporfin). Exclusion criteria were high myopia, 

 diagnosis of other retinal diseases, and other treatments for 

 macular diseases (dexamethasone implant, laser therapy, etc.). 

 Methods: We calculated incidence and prevalence based on the 

 age-matched general population in France. Adjustment for age and 

 sex was also performed for incidence. Main Outcome Measures: 

 Incidence and prevalence of nAMD in the French population 

 between 2008 and 2018. Results: Between 2008 and 2018, we 

 identified 342 961 patients with nAMD (67.5% women). Mean $±$ 

 standard deviation age at nAMD diagnosis or first treatment 

 increased from 78.8 $±$ 8.1 years in 2008 to 81.2 $±$ 7.9 

 years in 2018. In 2018, annual incidence was 0.149% and 

 prevalence was 1.062% for the French population 50 years of age 

 or older. Incidence was stable over the 10-year period. Annual 

 incidence increased with age (0.223%, 0.380%, and 0.603% in 

 those 60 years of age or older, 70 years of age or older, and 80 

 years of age or older, respectively), with similar trends for 

 prevalence. No major differences were observed among the 14 

 regions of France for incidence or prevalence. Neovascular 

 age-related macular degeneration incidence in 2018 was not 

 impacted by the availability of primary or ophthalmology care in 

 patients' localities. Conclusions: The LANDSCAPE study provides 

 exhaustive nationwide data on incidence and prevalence of nAMD 

 in France over a 10-year period.},

keywords = {age-related macular degeneration; Age-related macular   degeneration; France; ICD-10, AMD, International Classification of   Diseases, neovascular age-related macular   degeneration, Syst{è}me National des Donn{é}es de Sant{é}   (National Health Information Database); VEGF, Tenth Revision; Incidence; Neovascular; Prevalence;   SNDS, vascular   endothelial growth factor; nAMD},

pubstate = {published},

tppubtype = {article}

}

@article{Bechet2022-tb,

title = {Bruch membrane opening minimum rim width in neuromyelitis optica},

author = {Lorane Bechet and Philippe Cabre and Harold Merle},

year  = {2022},

date = {2022-03-01},

journal = {J. Neuroophthalmol.},

volume = {42},

number = {1},

pages = {e48–e55},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {BACKGROUND: Optical coherence tomography (OCT) analyzes the 

 neurodegeneration in neuromyelitis optica (NMO) and multiple 

 sclerosis (MS) and quantifies optical atrophy. The retinal nerve 

 fiber layer (RNFL) and ganglion cell layer (GCL) thickness are 

 decreased, and this structural change is correlated with visual 

 function of patients, including contrast vision and visual field 

 deviation. The main objective of this study was to evaluate the 

 Bruch membrane opening minimum rim width (BMO) of the patients 

 with NMO. METHODS: We studied the thickness of the BMO by OCT, in patients with NMO (n = 25; 34 eyes), MS (n = 50; 70 eyes), and a control group (n = 51; 100 eyes). The study evaluated the 

 structure-function relationship with the correlation between OCT 

 and visual function: Visual acuity, Pelli-Robson score, Sloan 

 2.5 and 1.25, color vision, standard automated perimetry (SAP), 

 and frequency-doubling technology perimetry (FDT). RESULTS: The 

 average thickness of BMO was significantly reduced in NMO and MS 

 with or without a history of optic neuritis (ON). Significant 

 thinning of the average, nasal, and inferonasal BMO in the absence of ON in NMO was found compared with controls (P = 

 0.022, 0.006, and 0.026, respectively). BMO was strongly 

 correlated with Pelli-Robson score (P < 0.001), Sloan 2.5 (P < 0.001), and mean deviation of SAP and FDT (P = 0.004). The 

 sectorial study found a high correlation between the BMO and the 

 corresponding sector of the visual field. CONCLUSIONS: The BMO 

 thickness is decreased after ON in NMO and MS. This study showed 

 an improved ability of BMO over RNFL and GCL to detect 

 infraclinical impairment in patients with NMO without a history 

 of optic neuropathy. Like the RNFL and GCL, BMO is well 

 correlated with visual function, including contrast vision and 

 visual field deviation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Charlot2022-nm,

title = {Mobile telemedicine screening for diabetic retinopathy using 

 nonmydriatic fundus photographs in burgundy: 11 years of results},

author = {Anthony Charlot and Florian Baudin and Mélanie Tessier and Sarah Lebrize and Victoire Hurand and Déborah Megroian and Louis Arnould and Inès Ben-Ghezala and Alain Marie Bron and Pierre-Henry Gabrielle and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-02-01},

journal = {J. Clin. Med.},

volume = {11},

number = {5},

pages = {1318},

publisher = {MDPI AG},

abstract = {We analyzed the results of mobile screening for diabetic 

 retinopathy (DR) using retinal photographs, comparing these 

 results between rural and periurban areas, and before and after 

 the first national COVID-19 pandemic lockdown. The Burgundy 

 Union Régionale des Professionnels de Santé (URPS) has 

 organized an annual DR screening since 2004. The examination, 

 performed by an orthoptist, consisted of taking the patient′s 

 history, intraocular pressure measurement, and taking retinal 

 photographs. After remote transmission, the examinations were 

 interpreted by participating ophthalmologists at the Dijon 

 University Hospital. In September 2016, the screening was open 

 to periurban townships. In 11 years, 10,220 patients were 

 screened: 1420 patients (13.9%) had DR of any type, with an 

 average age of 68.5 ($±$11.3) years, and 59.2% were men. 

 These patients had a statistically significantly higher glycated 

 hemoglobin level (7.4% vs. 7.0%) and a longer duration of 

 diabetes (13.8 vs. 9.3 years) than patients without DR. When 

 comparing rural and periurban areas and periods before and after 

 the beginning of the COVID-19 pandemic, we did not find any 

 significant difference in the screening results. The results of 

 this study are in line with the average findings of similar 

 studies comparing screening strategies for DR. The early 

 detection of DR can benefit from mobile telemedicine screening, 

 identifying a considerable number of patients at an elevated 

 risk, especially in rural areas where access to ophthalmological 

 care is limited.},

keywords = {diabetic retinopathy; screening; telemedicine},

pubstate = {published},

tppubtype = {article}

}

@article{Hannappe2022-fj,

title = {Mid-term impact of anti-vascular endothelial growth factor 

 agents on intraocular pressure},

author = {Marc-Antoine Hannappe and Florian Baudin and Anne-Sophie Mariet and Pierre-Henri Gabrielle and Louis Arnould and Alain M Bron and Catherine Creuzot-Garcher},

year  = {2022},

date = {2022-02-01},

journal = {J. Clin. Med.},

volume = {11},

number = {4},

pages = {946},

publisher = {MDPI AG},

abstract = {The effect of intraocular injections of anti-vascular 

 endothelial growth factor (VEGF) on intraocular pressure (IOP) 

 has not been clearly stated. We extracted data from the 

 electronic health records at Dijon University Hospital of 750 

 patients who were unilaterally injected with anti-VEGF agents 

 between March 2012 and March 2020. These were 

 treatment-naïve patients who had received at least three 

 injections of the same treatment (aflibercept, bevacizumab, or 

 ranibizumab) in one eye only, and had IOP measurements before 

 and after the injections. Fellow untreated eyes were used as 

 comparators. A clinically significant IOP rise was determined as 

 an IOP above 21 mmHg and an increase of at least 6 mmHg compared 

 to baseline, or the need for IOP-lowering agents. We found an 

 overall slight increase in IOP between treated and untreated 

 eyes at 6 months (+0.67 $±$ 3.33 mmHg, 95% confidence 

 interval 0.33–1.02, p},

keywords = {anti-VEGF agents; intraocular pressure; intravitreal injection},

pubstate = {published},

tppubtype = {article}

}

@article{Arnould2021-fl,

title = {Prediction of cardiovascular parameters with supervised machine 

 learning from Singapore ``I'' Vessel Assessment and 

 OCT-angiography: A pilot study},

author = {Louis Arnould and Charles Guenancia and Abderrahmane Bourredjem and Christine Binquet and Pierre-Henry Gabrielle and Pétra Eid and Florian Baudin and Ryo Kawasaki and Yves Cottin and Catherine Creuzot-Garcher and Sabir Jacquir},

year  = {2021},

date = {2021-11-01},

journal = {Transl. Vis. Sci. Technol.},

volume = {10},

number = {13},

pages = {20},

publisher = {Association for Research in Vision and Ophthalmology (ARVO)},

abstract = {Purpose: Assessment of cardiovascular risk is the keystone of 

 prevention in cardiovascular disease. The objective of this 

 pilot study was to estimate the cardiovascular risk score 

 (American Hospital Association [AHA] risk score, Syntax risk, 

 and SCORE risk score) with machine learning (ML) model based on 

 retinal vascular quantitative parameters. Methods: We proposed 

 supervised ML algorithm to predict cardiovascular parameters in 

 patients with cardiovascular diseases treated in Dijon 

 University Hospital using quantitative retinal vascular 

 characteristics measured with fundus photography and optical 

 coherence tomography - angiography (OCT-A) scans (alone and 

 combined). To describe retinal microvascular network, we used 

 the Singapore ``I'' Vessel Assessment (SIVA), which extracts 

 vessel parameters from fundus photography and quantitative OCT-A 

 retinal metrics of superficial retinal capillary plexus. 

 Results: The retinal and cardiovascular data of 144 patients 

 were included. This paper presented a high prediction rate of 

 the cardiovascular risk score. By means of the Naïve Bayes 

 algorithm and SIVA + OCT-A data, the AHA risk score was 

 predicted with 81.25% accuracy, the SCORE risk with 75.64% 

 accuracy, and the Syntax score with 96.53% of accuracy. 

 Conclusions: Performance of these algorithms demonstrated in 

 this preliminary study that ML algorithms applied to 

 quantitative retinal vascular parameters with SIVA software and 

 OCT-A were able to predict cardiovascular scores with a robust 

 rate. Quantitative retinal vascular biomarkers with the ML 

 strategy might provide valuable data to implement predictive 

 model for cardiovascular parameters. Translational Relevance: 

 Small data set of quantitative retinal vascular parameters with 

 fundus and with OCT-A can be used with ML learning to predict 

 cardiovascular parameters.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Baudin2021-hj,

title = {Functional and anatomical outcomes after successful repair of 

 macula-off retinal detachment: a 12-month follow-up of the 

 DOREFA study},

author = {Florian Baudin and Clémence Deschasse and Pierre-Henry Gabrielle and Jean P Berrod and Yannick Le Mer and Carl Arndt and Ramin Tadayoni and Marie N Delyfer and Michel Weber and David Gaucher and Maher Saleh and Christophe Chiquet and Catherine Creuzot-Garcher},

year  = {2021},

date = {2021-11-01},

journal = {Acta Ophthalmol.},

volume = {99},

number = {7},

pages = {e1190–e1197},

publisher = {Wiley},

abstract = {PURPOSE: To report visual and anatomical outcomes and determine 

 predictors of good visual acuity (VA) recovery after macula-off 

 rhegmatogenous retinal detachment (RD). METHODS: Prospective 

 multicentre study including 115 eyes from 115 patients 

 successfully operated on for RD, with assessment of VA and 

 spectral-domain optical coherence tomography (SD-OCT) macular 

 images at 1, 3, 6 and 12 months after surgery. RESULTS: Over the 

 follow-up period, VA significantly improved from median [IQR] 62 

 [46; 72] ETDRS letters at 1 month to 75 [67; 80] ETDRS letters 

 at 12 months (p < 0.001) with a concomitant decreased number of 

 eyes with any SD-OCT lesions (p < 0.001). The presence of 

 subretinal fluid (SRF) significantly decreased (p < 0.001), as did the number of photoreceptor (PR) layer lesions (p = 0.04). 

 At 12 months, lesions in the PR layer and poor VA recovery were significantly associated with a longer time to surgery (p = 

 0.007 and p < 0.001, respectively). The rate of patients without 

 PR lesions increased from 40.9% at 1 month to 60.0% at 6 

 months and 73.9% at 12 months (p < 0.001). The incidence of 

 epiretinal membrane (ERM) significantly increased (p < 0.001), 

 while cystoid macular oedema (CME) remained stable over time. 

 Visual acuity (VA) at 3 months postoperatively was a good 

 reflection of final VA recovery (p < 0.001). CONCLUSION: Visual 

 acuity (VA) improved in parallel with the decreasing number of 

 eyes with SD-OCT lesions after macula-off rhegmatogenous RD. A 

 long time to surgery was the only preoperative factor associated 

 with poor VA recovery after retinal detachment surgery.},

keywords = {cystoid macular oedema; external limiting membrane;   photoreceptor layer; rhegmatogenous retinal detachment;   spectral-domain optical coherence tomography; subretinal fluid;   vitreoretinal surgery},

pubstate = {published},

tppubtype = {article}

}

@article{Bechet2021-oc,

title = {Management of a case of Enhanced S-cone syndrome with massive 

 foveoschisis treated with pars plana vitrectomy with silicone 

 oil tamponade},

author = {Lorane Bechet and Raphaël Atia and Christina Zeitz and Saddek Mohand-Saïd and José-Alain Sahel and Pierre-Oliver Barale and Isabelle Audo},

year  = {2021},

date = {2021-10-01},

journal = {Ophthalmic Genet.},

volume = {42},

number = {5},

pages = {615–618},

publisher = {Informa UK Limited},

abstract = {Introduction: Goldmann Favre Syndrome (GFS) is a vitreoretinal 

 degenerative disease with macular retinoschisis. The current 

 treatment of foveoschisis is topical and oral carbonic anhydrase 

 inhibitors.Case: A 22-year-old male diagnosed with GFS presented 

 a progressive decrease in vision of the right eye. The optical 

 coherence tomography showed a significant macular schisis. A 

 medical treatment with topical and oral carbonic anhydrase 

 inhibitors was ineffective. We performed a pars plana vitrectomy 

 and silicone oil placement which led to an improvement of the 

 visual acuity and a reduction of the foveoschisis.Conclusion: We 

 describe here the first case of surgical treatment for macular 

 schisis in a patient with GFS.},

keywords = {Enhanced S-cone syndrome; Goldmann Favre syndrome; foveoschisis;   vitrectomy},

pubstate = {published},

tppubtype = {article}

}

@article{Baudin2021-fo,

title = {Quality-of-life improvement after scleral lens fitting in 

 patients with keratoconus},

author = {Florian Baudin and Alicia Chemaly and Louis Arnould and Elsa Barrénéchea and Lolita Lestable and Alain M Bron and Catherine Creuzot-Garcher},

year  = {2021},

date = {2021-09-01},

journal = {Eye Contact Lens},

volume = {47},

number = {9},

pages = {520–525},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {OBJECTIVES: To assess the quality-of-life improvement after 

 scleral lens fitting in patients with keratoconus. METHODS: We 

 conducted a prospective observational study of all consecutive 

 patients with keratoconus starting scleral lens fitting in 2019, 

 from January 2 to December 27, at the Dijon University Hospital, 

 France. Quality of life was assessed before and after wearing 

 scleral lenses for 3 months through the National Eye Institute 

 Visual Function Questionnaire 25 (NEI-VFQ 25) questionnaire. We 

 investigated factors potentially influencing quality of life: 

 final visual acuity, keratoconus stage, and maximum keratometry 

 reading. RESULTS: In total, 41 eyes of 24 patients were 

 successfully fitted with scleral lenses, 92.9% were 18 mm in 

 diameter and 7.1% were 17 mm. The visual acuity improved by 

 -0.4$±$0.3 logarithm of the minimum angle of resolution 

 (P<0.001) after scleral lens fitting. Visual gain increased with 

 keratometry and keratoconus severity (P<0.001; P<0.01). The 

 NEI-VFQ 25 score increased by 19.5$±$19.1 points on average 

 (P<0.001). No association was found between the factors under 

 study and improvement in quality of life. CONCLUSION: Our study 

 confirms the functional improvement in patients with keratoconus 

 fitted with scleral lenses, especially in patients with more 

 advanced disease. Moreover, it suggests a major role of these 

 lenses in improving quality of life, independently of the 

 severity of the disease and the visual gain.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nguyen2021-iv,

title = {Association between anatomical and clinical outcomes of 

 neovascular age-related macular degeneration treated with 

 antivascular endothelial growth factor},

author = {Vuong Nguyen and Martin Puzo and Jorge Sanchez-Monroy and Pierre-Henry Gabrielle and Catherine C Garcher and Florian Baudin and Benjamin Wolff and Laurent Castelnovo and Guillaume Michel and Louise O'Toole and Daniel Barthelmes and Mark C Gillies},

year  = {2021},

date = {2021-07-01},

journal = {Retina},

volume = {41},

number = {7},

pages = {1446–1454},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {PURPOSE: Assess the relationship between subretinal fluid 

 (SRFL), intraretinal fluid, and visual outcomes of neovascular 

 age-related degeneration in routine clinical practice. METHODS: 

 Treatment-naive eyes enrolled in the Fight Retinal Blindness! 

 registry after January 2017 were identified. Lesion activity was 

 graded at each visit as inactive, active not SRFL only (A-NSRFL 

 only), or active SRFL only (A-SRFL only). Eyes were grouped 

 based on initial activity as follows: 1) initially A-NSRFL only 

 or 2) initially A-SRFL only, and their predominant activity 

 status over 12 months was as follows: 1) mostly inactive, 2) 

 mostly A-NSRFL only, or 3) mostly A-SRFL only. RESULTS: Seven 

 hundred and three eyes were eligible for analysis. Initially 

 A-NSRFL only had a similar adjusted mean 12-month visual acuity change to initially A-SRFL eyes (5.7 vs. 6.9 letters; P = 

 0.165), but their final visual acuity was worse (62.5 vs. 67.5 letters at 12 months; P = 0.003). The adjusted mean 12-month 

 visual acuity change between the predominant activity groups was significantly different (P = 0.005), with mostly inactive (7.6 

 letters) and mostly A-SRFL only (7.5 letters) eyes gaining more 

 than mostly A-NSRFL only eyes (3.6 letters). CONCLUSION: Eyes 

 with SRFL only had similar outcomes at 1 year to eyes that were 

 mostly inactive. Intraretinal fluid was associated with worse 

 visual outcomes, highlighting the importance of distinguishing 

 between intraretinal fluid and SRFL when managing neovascular 

 age-related degeneration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lay2021-bd,

title = {The development of a high-resolution mass spectrometry method 

 for ultra-trace analysis of chlorinated dioxins in environmental 

 and biological samples including Viet Nam era veterans},

author = {Jackson O Lay and Rohana Liyanage and Jennifer A Gidden},

year  = {2021},

date = {2021-05-01},

journal = {Mass Spectrom. Rev.},

volume = {40},

number = {3},

pages = {236–254},

publisher = {Wiley},

abstract = {Chlorinated dioxins are labeled and recognized by both the World 

 Health Organization and the United Nations Environmental 

 Programme (UNEP) as ``persistent organic pollutants''. Their 

 potential for high toxicity is one of the primary factors behind 

 intense public and regulatory scrutiny and the need to measure 

 the compounds at very low limits, specifically the isomer 

 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). This article 

 highlights the early mass spectrometry methods to investigate, 

 detect, confirm, and quantify chlorinated dioxins and the 

 initial applications involving human biomonitoring, as attempts 

 were made to attribute health effects to TCDD exposure. This 

 effort represented a complex and difficult scientific response 

 to the pressing need to investigate expected exposures and 

 alleged subsequent medical effects, which in the case of the 

 Viet Nam veterans was being attempted a decade or more after 

 their exposure. It is noteworthy that this method and its 

 development touched on delicate issues involving human subjects, 

 war veterans, environmental contamination, and was difficult not 

 only scientifically, but for ethical and political reasons as 

 well. Stable-isotope dilution with analysis by gas 

 chromatography/high-resolution mass spectrometry (GC/HRMS) 

 became the method of choice because of its ability to monitor 

 characteristic ions and isotope ratios to quantify and 

 qualify/confirm the analyte in the presence of coextracting and 

 coeluting interferences at these low levels with the highest 

 possible confidence. This method was rigorously tested and 

 validated before it was used to discover and monitor levels in 

 the environment and in various populations at then unprecedented 

 low levels. These early studies demonstrated the feasibility of 

 monitoring dioxins in humans even decades after exposure, and 

 led to the detection of 2,3,7,8-TCDD in the general population 

 as well as specific overexposed populations. These studies also 

 provided strong evidence regarding the origins of the 

 2,3,7,8-isomer in the environment. © 2020 John Wiley 

 & Sons Ltd. Mass Spec Rev.},

keywords = {TCDD; dioxin; high resolution mass spectrometry; ultra-trace   analysis},

pubstate = {published},

tppubtype = {article}

}

@article{Chemaly2021-bt,

title = {Plasma fatty acids and primary open-angle glaucoma in the 

 elderly: the Montrachet population-based study},

author = {Alicia Chemaly and Louis Arnould and Alassane Seydou and Pierre-Henry Gabrielle and Florian Baudin and Niyazi Acar and Catherine Creuzot-Garcher},

year  = {2021},

date = {2021-03-01},

journal = {BMC Ophthalmol.},

volume = {21},

number = {1},

pages = {146},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: To compare plasma fatty acids (FAs) between 

 participants with primary open-angle glaucoma (POAG) and 

 participants without neuropathy in an elderly population and to 

 investigate specific FAs pattern in POAG. METHODS: We conducted 

 a population-based study in participants older than 75 years. 

 Participants underwent a comprehensive eye examination with 

 optic nerve photographs, visual field test and optic nerve OCT 

 with RNFL thickness measurement. Glaucomatous status was defined 

 according to the International Society for Epidemiologic and 

 Geographical Ophthalmology classification. Lipids were extracted 

 from plasma and FAs methylesters prepared and analyzed by gas 

 chromatography-mass spectrometry. RESULTS: Among the 1153 

 participants of the Montrachet study 810 were retained for 

 analysis and 68 had POAG. The mean age was 82.11 $±$ 3.67. In 

 multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern 

 characterized by high negative weight of gamma-linoleic acid, 

 eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 

 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive 

 weight of eicosadienoic acid, docosatetraenoic acid, 

 docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid 

 MUFAs, margaric acid and behenic acid saturated FAs was 

 positively associated with POAG. After adjustment for major 

 confounders, individuals in the upper tertile of FAs pattern 

 scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29-7.40] P = 0.013). 

 CONCLUSIONS: We found no significant difference regarding 

 isolated plasma FAs between participants with POAG and 

 participants without neuropathy in elderly but specific FAs 

 pattern might be associated with POAG.},

keywords = {Elderly; Fatty acids profile; Glaucoma; Montrachet study;   Population-based study},

pubstate = {published},

tppubtype = {article}

}

@article{Nove-Josserand2021-oi,

title = {Subcapularis tendon tear: A structure-based arthroscopic 

 description},

author = {Laurent Nové-Josserand and Thomas Chauvet and Florian Baudin and Arnaud Godenèche and Philippe Collotte and Thais Dutra Vieira and Emil Haritinian},

year  = {2021},

date = {2021-02-01},

journal = {Orthop. Traumatol. Surg. Res.},

volume = {107},

number = {1},

pages = {102757},

publisher = {Elsevier BV},

abstract = {INTRODUCTION: Subscapularis (SSC) tendons differ from 

 supraspinatus tendons, although both have similar histologic 

 structure comprising two layers with distinct collagen fiber 

 organization. HYPOTHESIS: The partial/full-thickness tear 

 classification for the supraspinatus based on tendon structure 

 can be applied to the subscapularis tendon on objective 

 criteria. MATERIAL AND METHODS: The present study used 100 films 

 of arthroscopic rotator cuff repair involving SSC lesion. 

 Lesions were reported on 3 objective criteria: horizontal 

 superior tendon edge visibility, lesser tuberosity bone 

 exposure, and lateral tendon edge visibility. Combining the 

 three distinguishes deep, superficial or interstitial partial 

 tear versus full-thickness tear. Degree of retraction was also 

 noted. RESULTS: Forty-six of the 73 partial lesions involved the 

 deep articular layer, which was often retracted, but conserving 

 the horizontal superior tendon edge and thus misleadingly 

 suggesting SSC integrity; 23 were interstitial, without 

 detachment from the lesser tuberosity; 4 involved only the 

 superficial layer. Full-thickness tears were always retracted, 

 with loss of horizontal superior tendon edge, visibility of the 

 lateral tendon edge and presence of comma sign. Inter- and 

 intra-observer reproducibility was satisfactory. DISCUSSION - 

 CONCLUSION: Like in superior cuff tear, a structure-based 

 classification can be made of SSC lesions on objective criteria. 

 LEVEL OF EVIDENCE: IV.},

keywords = {Classification; Histology; Shoulder; Subscapularis tendon; Tear},

pubstate = {published},

tppubtype = {article}

}

@article{Maupin2020-tv,

title = {Accuracy of the ISNT rule and its variants for differentiating 

 glaucomatous from normal eyes in a population-based study},

author = {Edouard Maupin and Florian Baudin and Louis Arnould and Allasane Seydou and Christine Binquet and Alain M Bron and Catherine P Creuzot-Garcher},

year  = {2020},

date = {2020-10-01},

journal = {Br. J. Ophthalmol.},

volume = {104},

number = {10},

pages = {1412–1417},

publisher = {BMJ},

abstract = {AIMS: To evaluate the accuracy of the ISNT rule (I=inferio},

keywords = {epidemiology; glaucoma},

pubstate = {published},

tppubtype = {article}

}

@article{Chauvet2020-ua,

title = {The invisible MGHL test: Diagnostic value and benefits for the 

 repair of retracted subscapularis tears},

author = {Thomas Chauvet and Emil Haritinian and Florian Baudin and Philippe Collotte and Laurent Nové-Josserand},

year  = {2020},

date = {2020-07-01},

journal = {Am. J. Sports Med.},

volume = {48},

number = {9},

pages = {2144–2150},

publisher = {SAGE Publications},

abstract = {BACKGROUND: Some full-thickness subscapularis tendon tears and 

 partial tears of the deep layer are difficult to characterize, 

 leading to misdiagnosis. PURPOSE: To evaluate the association 

 between displacement of the middle glenohumeral ligament (MGHL) 

 and retracted tears of the subscapularis tendon as a possible 

 test to improve diagnosis. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Videos (N = 100) recorded during 

 arthroscopic rotator cuff repair involving a torn subscapularis 

 tendon were analyzed retrospectively to assess the association 

 between the MGHL test (nonvisibility of the MGHL) and other 

 objective anatomic criteria. The invisible MGHL test was defined 

 as positive if the MGHL was initially nonvisible in the 

 beach-chair position and appeared only when the subscapularis 

 tendon was pulled back into position by using a 30° arthroscope 

 from the standard posterior portal. The parameters considered 

 during the initial exploration were (1) visibility of the 

 horizontal part of the subscapularis tendon; (2) visibility of 

 the MGHL in its usual position, crossing the superior border of 

 the subscapularis tendon; (3) exposure of the lateral border of 

 the subscapularis tendon (full-thickness retracted tear); and 

 (4) complete or partial exposure of the lesser tuberosity of the 

 humerus. Tendon retraction was evaluated in 3 stages according 

 to the Patte classification. RESULTS: The invisible MGHL test 

 result was positive in 45% of cases. It was positive in 6% of 

 cases (2 of 31) when there was no subscapularis tendon 

 retraction and in 62% of cases (43 of 69) when there was 

 partial or complete retraction (P < .001). The invisible MGHL 

 test was significantly associated with the width of the tear (P 

 < .001) and exposure of the lateral border of the subscapularis tendon (full-thickness retracted tea},

keywords = {diagnostic test; middle glenohumeral ligament; retraction;   shoulder; subscapularis; tear},

pubstate = {published},

tppubtype = {article}

}

@article{Bhandari2020-xm,

title = {Ranibizumab or aflibercept for diabetic macular edema: 

 Comparison of 1-year outcomes from the Fight Retinal Blindness! 

 Registry},

author = {Sanjeeb Bhandari and Vuong Nguyen and Samantha Fraser-Bell and Hemal Mehta and Francesco Viola and Florian Baudin and Pierre-Henry Gabrielle and Catherine Creuzot-Garcher and Mark Gillies and Daniel Barthelmes},

year  = {2020},

date = {2020-05-01},

journal = {Ophthalmology},

volume = {127},

number = {5},

pages = {608–615},

publisher = {Elsevier BV},

abstract = {PURPOSE: Both ranibizumab and aflibercept improved vision and 

 decreased macular thickness in eyes with diabetic macular edema 

 (DME) in clinical trials. This study compared the 12-month 

 treatment outcomes of each drug in routine clinical practice. 

 DESIGN: Retrospective analysis of data from the prospectively 

 designed observational Fight Retinal Blindness! registry. 

 PARTICIPANTS: Treatment-naive eyes tracked in the registry that 

 initiated treatment with either ranibizumab (0.5 mg) or 

 aflibercept (2 mg) for DME from December 1, 2013, through June 

 1, 2018. METHODS: Visual acuity (VA) was analyzed at 12 months 

 in all eyes (completers, noncompleters, and eyes that switched 

 treatment). MAIN OUTCOME MEASURES: The primary outcome was the 

 mean change in VA from baseline to 12 months. RESULTS: We identified 383 eyes (ranibizuma},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ben_Ghezala2020-ex,

title = {Incidence of acute postoperative endophthalmitis following 

 macular surgery in France between 2006 and 2016},

author = {Inès Ben Ghezala and Anne-Sophie Mariet and Eric Benzenine and Alain M Bron and Florian Baudin and Vincent Daien and Jean-François Korobelnik and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2020},

date = {2020-05-01},

journal = {Acta Ophthalmol.},

volume = {98},

number = {3},

pages = {e333–e338},

publisher = {Wiley},

abstract = {PURPOSE: To report the incidence of acute postoperative 

 endophthalmitis (POE) after macular surgery in France between 

 2006 and 2016 and to identify associated factors. METHODS: This 

 retrospective database study included all hospital discharge 

 records involving a surgical procedure for an epiretinal 

 membrane or a macular hole in France from January 2006 to 

 October 2016. Acute POE was identified by two codes in the tenth 

 edition of the International Classification of Diseases within 

 42 days of a macular surgical procedure in the French national 

 administrative database. RESULTS: In France, 152 034 macular 

 surgical procedures for epiretinal membranes or macular holes 

 were recorded from 1 January 2006 to 31 October 2016. Suspected 

 acute POE was reported in 381 cases. The incidence of POE was 

 0.25% overall, 0.30% for epiretinal membrane surgery and 

 0.14% for macular hole surgery. In multivariable Poisson 

 regression analysis, epiretinal membrane surgery was associated 

 with POE [incidence rate ratio (IRR), 2.24; 95% CI, 1.62-3.11; 

 p < 0.001]. For epiretinal membrane surgery, the 2010-2011 

 period was significantly associated with a higher risk of POE (IRR, 1.66; 95% CI, 1.13-2.42; p = 0.03). CONCLUSION: The 

 incidence of POE after macular surgery was 0.25% overall in 

 France between 2006 and 2016 and twice higher for epiretinal 

 membrane surgery than for macular hole surgery. For epiretinal 

 surgery only, the incidence of POE was higher in 2010-2011 

 (period of the switch to transconjunctival vitrectomy) than in 

 the rest of the study period.},

keywords = {endophthalmitis; epidemiology; epiretinal membrane; macular   hole; pars plana vitrectomy; transconjunctival sutureless   vitrectomy},

pubstate = {published},

tppubtype = {article}

}

@article{Guillemin2020-uw,

title = {Kystes péripupillaires bilatéraux chez un patient de 30 

 ans},

author = {M Guillemin and J Blanc and F Baudin and D Haddad and A M Bron and C Creuzot-Garcher},

year  = {2020},

date = {2020-04-01},

journal = {J. Fr. Ophtalmol.},

volume = {43},

number = {4},

pages = {373–375},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arnould2020-bo,

title = {Influence of cardiac hemodynamic variables on retinal vessel 

 density measurement on optical coherence tomography angiography 

 in patients with myocardial infarction},

author = {L Arnould and C Guenancia and P-H Gabrielle and S Pitois and F Baudin and T Pommier and M Zeller and A M Bron and C Creuzot-Garcher and Y Cottin},

year  = {2020},

date = {2020-03-01},

journal = {J. Fr. Ophtalmol.},

volume = {43},

number = {3},

pages = {216–221},

publisher = {Elsevier BV},

abstract = {INTRODUCTION: Quantitative measurements of retinal 

 microvasculature by optical coherence tomography angiography 

 (OCT-A) have been used to assess cardiovascular risk profile. 

 However, to date, there are no studies focusing on OCT-A imaging 

 in the setting of the altered hemodynamic status found in 

 high-risk cardiovascular patients. METHODS: To determine the 

 potential association between retinal vascular density on OCT-A 

 and a comprehensive battery of hemodynamic variables in patients 

 with myocardial infarction (MI) using data from the acute phase 

 and at 3 months follow-up after cardiac rehabilitation. This 

 prospective longitudinal study included patients who presented 

 with MI in the cardiology intensive care unit at Dijon 

 University Hospital. Main outcomes and measurements were retinal 

 vessel density on OCT-A, hemodynamic status based on left 

 ventricular ejection fraction (LVEF), and indexed cardiac output 

 during the acute phase of myocardial infarction and at 3 months 

 follow-up. RESULTS: Overall, 30 patients were included in this 

 pilot study. The median (IQR) age was 64 years (55-71) with 87% 

 men. At admission, the mean (SD) LVEF was 53% (11), and the 

 mean indexed cardiac output was 2.70 (0.83) L/min/m2. On OCT-A, 

 the mean inner retinal vascular density was 19.09 (2.80) mm-1. 

 No significant association was found between retinal vascular 

 density and hemodynamic variables. CONCLUSION: We found no 

 significant association between retinal vascular density on 

 OCT-A and hemodynamic variables in the acute phase of a 

 myocardial infarction or after 3 months of cardiac 

 rehabilitation. Therefore, OCT-A findings do not seem to be 

 influenced by the hemodynamic changes associated with myocardial 

 infarction.},

keywords = {Cardiovascular disease;   R{é}tine, Infarction infarctus du myocarde; Maladie cardiaque   ath{é}roscl{é}rotique; OCT angiographie; Retina, Myocardial infarction, OCT   angiography},

pubstate = {published},

tppubtype = {article}

}

@article{Gabrielle2019-ki,

title = {Subretinal drusenoid deposits in the elderly in a 

 population-based study (the Montrachet study)},

author = {Pierre-Henry Gabrielle and Alassane Seydou and Louis Arnould and Niyazi Acar and Hervé Devilliers and Florian Baudin and Ines Ben Ghezala and Christine Binquet and Alain Marie Bron and Catherine Creuzot-Garcher},

year  = {2019},

date = {2019-11-01},

journal = {Invest. Ophthalmol. Vis. Sci.},

volume = {60},

number = {14},

pages = {4838–4848},

publisher = {Association for Research in Vision and Ophthalmology (ARVO)},

abstract = {Purpose: The aim of this study was to investigate the prevalence 

 of subretinal drusenoid deposits (SDD) and to identify 

 associated factors in an elderly population. Methods: The 

 participants of the population-based Montrachet study underwent 

 an exhaustive ophthalmologic examination, including color fundus 

 photography and macular spectral domain-optical coherence 

 tomography (SD-OCT), coupled with infrared reflectance imaging. 

 The presence of SDD and other age-related macular degeneration 

 lesions, according to the European Eye Epidemiology SD-OCT 

 classification of macular diseases, and subfoveal choroidal 

 thickness were recorded. Moreover, the association of SDD and 

 both clinical and demographic factors as well as plasma levels 

 of vitamin E and lutein/zeaxanthin (L/Z) were analyzed. Results: 

 The mean age of patients was 82.3 $±$ 3.8 years and 62.7% were female. The prevalence of SDD was 18.1% (n = 205) in the subjects with at least one eye interpretable (n = 1135). In 

 multivariate analysis, SDD was positively associated with 

 increasing age (OR, 4.6; 95% CI, 2.8-7.7; P 85 years), female sex (OR, 1.7; 95% CI, 1.2-2.4; P = 0.005), and plasma L/Z level (OR, 1.2; 95% CI, 1.0-1.5; P = 0.039), and negatively 

 associated with lipid-lowering drugs use (OR, 0.5; 95% CI, 0.3-0.9; P = 0.014 for statin medications) and subfoveal choroidal thickness (OR, 0.8; 95% CI, 0.7-0.9; P = 0.002). 

 Conclusions: The prevalence of SDD was high in subjects older 

 than 75 years, more frequent in women, and was associated with a 

 thinner choroid. The association with lipid-lowering drugs 

 deserves further investigation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bechet2019-vx,

title = {Des microkystes maculaires chez une enfant atteinte de 

 neuromyélite optique : à propos d'un cas},

author = {L Bechet and H Merle},

year  = {2019},

date = {2019-04-01},

journal = {J. Fr. Ophtalmol.},

volume = {42},

number = {4},

pages = {e187–e191},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bechet2019-ql,

title = {Fovea Plana in a 9-year-old boy presenting with decreased vision 

 in the left eye},

author = {Lorane Bechet and Rabih Hage and Agathe Vest and Albert Jean-Charles and Harold Merle},

year  = {2019},

date = {2019-04-01},

journal = {Am. J. Case Rep.},

volume = {20},

pages = {537–541},

publisher = {International Scientific Information, Inc.},

abstract = {BACKGROUND Foveal hypoplasia (FH) is a congenital disorder, 

 generally associated with other conditions. CASE REPORT A 

 9-year-old boy presented with moderately decreased vision in the 

 left eye. Fundus examination showed an absence of macular 

 reflection and no foveal pit was seen on optical coherence 

 tomography. Fluorescein angiography demonstrated the absence of 

 a foveal avascular zone. CONCLUSIONS This is a rare case of a 

 unilateral fovea plana associated with a visual impairment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Baudin2018-da,

title = {Association of acute endophthalmitis with intravitreal 

 injections of corticosteroids or anti-vascular growth factor 

 agents in a nationwide study in France},

author = {Florian Baudin and Eric Benzenine and Anne-Sophie Mariet and Alain M Bron and Vincent Daien and Jean Franc cois Korobelnik and Catherine Quantin and Catherine Creuzot-Garcher},

year  = {2018},

date = {2018-12-01},

journal = {JAMA Ophthalmol.},

volume = {136},

number = {12},

pages = {1352–1358},

publisher = {American Medical Association (AMA)},

abstract = {Importance: The number of patients affected by retinal diseases 

 treated with intravitreal injections (IVTs) has resulted in a 

 rapidly growing number of procedures. One of the worst 

 complications after these injections is endophthalmitis. 

 Objective: To evaluate the incidence of acute endophthalmitis 

 after IVTs of corticosteroids or anti-vascular endothelial 

 growth factor (anti-VEGF) agents. Design, Setting, and 

 Participants: This population-based cohort study included 

 patients undergoing IVTs from January 1, 2012, through December 

 31, 2015, in France. Data were acquired from the French 

 medical-administrative database (Système National 

 d'Information Inter-Régime de l'Assurance Maladie), which 

 collects hospitalization discharge abstracts and out-of-hospital 

 care information for the whole country. Data were analyzed from 

 March through July 2017. Exposures: Intravitreal injections of 

 corticosteroid or anti-VEGF agents. Main Outcomes and Measures: 

 Incidence of acute endophthalmitis within 6 weeks after IVT by 

 means of billing codes from a national database. Results: During 

 the study period, 1 811 977 IVTs of corticosteroids or anti-VEGF 

 agents performed on 254 927 patients (60.4% female; median age, 

 79 years [interquartile range, 70-85 years]) were analyzed. A 

 total of 444 acute endophthalmitis cases (crude incidence, 

 0.0245%) were recorded. In multivariable analysis, which did 

 not include adjustment for when the endophthalmitis occurred 

 during the study period, the risk of endophthalmitis was lower 

 in male patients (incidence rate ratio [IRR], 0.78; 95% CI, 0.63-0.96; P = .02), higher for corticosteroids than for 

 anti-VEGF agents (IRR, 3.21; 95% CI, 2.33-4.44; P < .001), and 

 higher for nonprefilled syringes of anti-VEGF medications than 

 prefilled syringes for ranibizumab (IRR, 1.63; 95% CI, 

 1.15-2.30) and aflibercept (IRR, 1.82; 95% CI, 1.25-2.66; P < 

 .001). Conclusions and Relevance: The findings from this study 

 of a nationwide database appear to have confirmed the low 

 incidence rate of acute endophthalmitis after IVTs of 

 corticosteroids or anti-VEGF agents. Although an association may 

 not necessarily indicate a cause and effect, the risk for acute 

 endophthalmitis after IVTs appeared to be higher for 

 corticosteroids compared with anti-VEGF agents, while a lower 

 risk of endophthalmitis appeared to be found with prefilled 

 syringes of anti-VEGF medications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vest2018-va,

title = {Une dégénérescence marginale de Terrien chez une 

 enfant de 6 ans : à propos d'un cas},

author = {A Vest and A Jean-Charles and L Bechet and N Plasse and N Paul and H Merle},

year  = {2018},

date = {2018-11-01},

journal = {J. Fr. Ophtalmol.},

volume = {41},

number = {9},

pages = {e433–e435},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Faroux2018-uj,

title = {Reduction in exposure of interventional cardiologists to ionising 

 radiation over a 10-year period},

author = {Laurent Faroux and Thierry Blanpain and Pierre Nazeyrollas and Sophie Tassan-Mangina and Virginie Heroguelle and Christophe Tourneux and Florian Baudin and Damien Metz},

year  = {2018},

date = {2018-05-01},

journal = {Int. J. Cardiol.},

volume = {259},

pages = {57–59},

abstract = {Exposure of operators to ionising radiation in interventional 

 cardiology has likely diminished, but data confirming the 

 magnitude of the reduction are lacking. The aim of this study was 

 to compare the dose of radiation received by interventional 

 cardiology operators at 11 years interval (2006 vs 2017). The 

 study population comprised all interventional coronary procedures 

 performed by a single operator in one catheterization laboratory 

 (cathlab) of a large university hospital in north-eastern France. 

 Exposure was compared between two periods, namely period 1 (from 

 October 2005 to March 2006) and period 2 (from March 2017 to June 

 2017). The primary endpoint was the dose of radiation received by 

 the operator, measured using an electronic dosimeter placed on 

 the operator's left arm. In 2017, the dose of radiation received 

 by the operators was, on average, 95% lower than the dose 

 received in 2006 (p < 0.0001), even though the average 

 fluoroscopy time increased by 73% over the same period (p < 

 0.0001). By multivariable analysis including body mass index, 

 fluoroscopy time and performance of at least one (1) coronary 

 angioplasty, the reduction in the operator's exposure to 

 radiation remained significant. The dose of radiation received by 

 interventional cardiology operators has decreased by 95% over 

 the last ten years.},

keywords = {Cardiac catheterization; Coronary artery; Radiation risk},

pubstate = {published},

tppubtype = {article}

}

@article{Faroux2018-lx,

title = {Effect of modern dose-reduction technology on the exposure of 

 interventional cardiologists to radiation in the catheterization 

 laboratory},

author = {Laurent Faroux and Thierry Blanpain and Pierre Nazeyrollas and Sophie Tassan-Mangina and Virginie Heroguelle and Christophe Tourneux and Florian Baudin and Damien Metz},

year  = {2018},

date = {2018-01-01},

journal = {JACC Cardiovasc. Interv.},

volume = {11},

number = {2},

pages = {222–223},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Barrenechea2017-ou,

title = {Retinal phacomas in tuberous sclerosis in a 18-year old patient},

author = {E Barrenechea and C Deschasse and F Baudin and A M Bron and C Creuzot Garcher},

year  = {2017},

date = {2017-12-01},

journal = {J. Fr. Ophtalmol.},

volume = {40},

number = {10},

pages = {898–900},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Deschasse2017-ak,

title = {Spasme du dilatateur pupillaire ou pupille en têtard},

author = {C Deschasse and F Baudin and P H Gabrielle and A M Bron and C Creuzot-Garcher},

year  = {2017},

date = {2017-06-01},

journal = {J. Fr. Ophtalmol.},

volume = {40},

number = {6},

pages = {522–523},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bonnin2013-ei,

title = {Spontaneous closure of macular holes secondary to posterior 

 uveitis: case series and a literature review},

author = {Nicolas Bonnin and Pierre-Loïc Cornut and Florian Chaise and Elodie Labeille and Helene Janin Manificat and Audrey Feldman and Laurent Perard and Franck Bacin and Frédéric Chiambaretta and Carole Burillon},

year  = {2013},

date = {2013-02-01},

journal = {J. Ophthalmic Inflamm. Infect.},

volume = {3},

number = {1},

pages = {34},

publisher = {Springer Nature},

abstract = {The occurrence of a macular hole due to posterior uveitis is 

 infrequently reported. We report the evolution of three cases of 

 macular holes secondary to posterior segment inflammation. A 

 complete inflammatory and infectious assessment found one case 

 of toxocariasis, one of sarcoidosis, and one of syphilis. After 

 medical etiological treatment, macular hole closure was rapidly 

 obtained in all the cases and confirmed by spectral domain optic 

 coherence tomography, with visual acuity improvement. Fibrous 

 scarring developed in two cases, and foveal photoreceptor 

 complex normalization was observed in the sarcoidosis case. 

 These observations demonstrate that macular holes secondary to 

 posterior uveitis frequently resolve without surgical 

 intervention and so could be underdiagnosed if the patient is 

 not evaluated at the time of onset before spontaneous hole 

 closure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}